Oxidative Stress In The Serum Of Exercised Rats Supplemented With Creatine

PURPOSE: There is evidence that creatine may exert antioxidant activities. This study analyzes the effects of aerobic training and creatine supplementation on biomarkers of oxidative stress in the serum of rats. METHODS: Adults male wistar (90 day old) rats were submitted to a Maximal Lactate Steady...

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Published in:Medicine and science in sports and exercise 2012-05, Vol.44 (5S), p.604-604
Main Authors: Araujo, Michel B, Moura, Leandro P, Dalia, Rodrigo A, Voltarelli, Fabricio A, Sponton, Amanda C, Mello, Maria Alice R
Format: Article
Language:English
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Summary:PURPOSE: There is evidence that creatine may exert antioxidant activities. This study analyzes the effects of aerobic training and creatine supplementation on biomarkers of oxidative stress in the serum of rats. METHODS: Adults male wistar (90 day old) rats were submitted to a Maximal Lactate Steady State (MLSS) test in order to identify the aerobic/anaerobic metabolic transition during treadmill running. Soon afterwards, the rats were divided into 6 groups: Trained Creatine (TCr), Trained (T), Trained Maltodextrin (TM), Control Creatine (CCr), Control Maltodextrin (CM) and Control (C). Trained rats ran on a treadmill for 40 minutes per day, 5 days per week for 8 weeks, at a speed equivalent to per individual MLSS. Creatine supplemented rats received creatine monohydrate per 5 days per week (0.107g/kg body weight (b.w)) and maltodextrin (0.160g/kg b.w), by gavage during the 8 weeks. The maltodextrin supplemented rats received maltodextrin (0.160g/kg b.w) by gavage. At the end of the experiment, all the rats were sacrificed and the amount of the substances that reacted with thiobarbituric acid (TBARs) and catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-GPx) activities in the serum were analyzed. RESULTS: The amount of TBARs was not different among the groups. There also were no significant differences between the groups in relationship to CAT and SOD activities. On the other hand, GSH-GPx activity was lower in the TM group(2.24+1.75) group than other groups (TCr 3.87+1.47; T 2.85+1.63; CCr 5.60+1.73; CM 4.28+2.32 and C 2.85+1.06). CONCLUSION: These results suggest that neither exercise or supplementation did not affect the redox state of the animals.
ISSN:0195-9131