MicroRNA-30d-5p inhibits tumour cell proliferation and motility by directly targeting CCNE2 in non-small cell lung cancer

Highlights • MiR-30d-5p significantly inhibits the growth of NSCLC cells in vivo. • MiR-30d-5p significantly inhibits invasion and migration of NSCLC cells in vitro. • Cyclin E2 (CCNE2) is a direct functional target of miR-30d-5p in NSCLC cells. • CCNE2 over-expression promotes the proliferation, in...

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Bibliographic Details
Published in:Cancer letters 2015-07, Vol.362 (2), p.208-217
Main Authors: Chen, Di, Guo, Weijie, Qiu, Zhaoping, Wang, Qifeng, Li, Yan, Liang, Linhui, Liu, Li, Huang, Shenglin, Zhao, Yingjun, He, Xianghuo
Format: Article
Language:English
Subjects:
3' Untranslated Regions
Animals
Binding sites
Carcinogenesis
Carcinoma, Non-Small-Cell Lung - genetics
Carcinoma, Non-Small-Cell Lung - metabolism
Carcinoma, Non-Small-Cell Lung - pathology
CCNE2
Cell cycle
Cell growth
Cell Growth Processes - genetics
Cell Line, Tumor
Cell Movement - genetics
Colonies & territories
Cyclins - biosynthesis
Cyclins - genetics
Deoxyribonucleic acid
DNA
Down-Regulation
HEK293 Cells
Hematology, Oncology and Palliative Medicine
Heterografts
Humans
Lung cancer
Lung Neoplasms - genetics
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Male
Metastasis
Mice
Mice, Inbred BALB C
Mice, Nude
MicroRNAs - genetics
MicroRNAs - metabolism
miR-30d
Mortality
Motility
Non-small cell lung cancer
Proliferation
Rodents
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Summary:Highlights • MiR-30d-5p significantly inhibits the growth of NSCLC cells in vivo. • MiR-30d-5p significantly inhibits invasion and migration of NSCLC cells in vitro. • Cyclin E2 (CCNE2) is a direct functional target of miR-30d-5p in NSCLC cells. • CCNE2 over-expression promotes the proliferation, invasion, and migration of NSCLC cells.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2015.03.041