Entamoeba histolytica: Signaling through G Proteins

Paveto, C., Torres, H. N., Flavia, M. M., Garcı́a-Espitia, M., Ortega, A., and Orozco, E. 1999.Entamoeba histolytica: Signaling through G proteins.Experimental Parasitology91,170–175. The intracellular signaling pathways ofEntamoeba histolyticaare largely unknown. Although the expression of guanine...

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Published in:Experimental parasitology 1999-02, Vol.91 (2), p.170-175
Main Authors: Paveto, Cristina, Torres, Héctor N., Flawia, Mirtha M., Garcı́a-Espitia, Matilde, Ortega, Arturo, Orozco, Esther
Format: Article
Language:English
Subjects:
Adenylyl Cyclases - analysis
Animals
Biochemistry. Physiology. Immunology. Molecular biology
Biological and medical sciences
Blotting, Western
Cells, Cultured
Cholera Toxin - pharmacology
Cyclic AMP - analysis
Electrophoresis, Polyacrylamide Gel
Entamoeba histolytica
Entamoeba histolytica - metabolism
Fundamental and applied biological sciences. Psychology
GTP-Binding Proteins - chemistry
GTP-Binding Proteins - immunology
GTP-Binding Proteins - physiology
Guanosine 5'-O-(3-Thiotriphosphate) - chemistry
Immune Sera - immunology
Immunohistochemistry
Protozoa
Signal Transduction
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Summary:Paveto, C., Torres, H. N., Flavia, M. M., Garcı́a-Espitia, M., Ortega, A., and Orozco, E. 1999.Entamoeba histolytica: Signaling through G proteins.Experimental Parasitology91,170–175. The intracellular signaling pathways ofEntamoeba histolyticaare largely unknown. Although the expression of guanine nucleotide binding proteins (G proteins) is expected from functional studies, their biochemical characterization remains elusive in this protozoan. Using a combination of biochemical and immunological studies, we provide strong evidence for the presence of a Gsprotein in amoeba. Our results streghthen our understanding of the signal transduction mechanisms inE. histolyticaas potential sites of a new therapeutic strategy.
ISSN:0014-4894
1090-2449
DOI:10.1006/expr.1998.4361