Recent advances from studies on the role of structural proteins in enterovirus infection

Enteroviruses are a large group of small nonenveloped viruses that cause common and debilitating illnesses affecting humans and animals worldwide. The capsid composed by viral structural proteins packs the RNA genome. It is becoming apparent that structural proteins of enteroviruses play versatile r...

Full description

Saved in:
Bibliographic Details
Published in:Future microbiology 2015-09, Vol.10 (9), p.1529-1542
Main Authors: Wen, Xingjian, Cheng, Anchun, Wang, Mingshu, Jia, Renyong, Zhu, Dekang, Chen, Shun, Liu, Mafeng, Sun, Kunfeng, Yang, Qiao, Wu, Ying, Chen, Xiaoyue
Format: Article
Language:English
Subjects:
Animals
Antiviral Agents - therapeutic use
Antiviral drugs
antiviral strategies
Apoptosis
Binding sites
Capsid Proteins - physiology
Chronic illnesses
Cytoplasm
Development and progression
Enterovirus - chemistry
Enterovirus - pathogenicity
Enterovirus infections
Enterovirus Infections - therapy
Enterovirus Infections - virology
Enteroviruses
Enzymes
Genetic aspects
Genomes
host cellular factors
Host-Pathogen Interactions
Humans
Infections
Life cycles
nonstructural functions
P1 proteins
Pathogenesis
Polypeptides
Properties
Proteins
Ribonucleic acid
RNA
Sediments
Structural proteins
Viral infections
Viral proteins
Viral Structural Proteins - physiology
Virulence
Virulence (Microbiology)
Virus Replication
virus-host interaction
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Enteroviruses are a large group of small nonenveloped viruses that cause common and debilitating illnesses affecting humans and animals worldwide. The capsid composed by viral structural proteins packs the RNA genome. It is becoming apparent that structural proteins of enteroviruses play versatile roles in the virus-host interaction in the viral life cycle, more than just a shell. Furthermore, structural proteins to some extent may be associated with viral virulence and pathogenesis. Better understanding the roles of structural proteins in enterovirus infection may lead to the development of potential antiviral strategies. Here, we discuss recent advances from studies on the role of structural proteins in enterovirus infection and antiviral therapeutics targeted structural proteins.
ISSN:1746-0913
1746-0921
DOI:10.2217/fmb.15.62