Risk factors for small bowel bleeding in chronic nonsteroidal anti-inflammatory drug users

Objective The incidence of nonsteroidal anti‐inflammatory drugs (NSAIDs)‐induced enteropathy is currently increasing. However, the predictors of small bowel bleeding (SBB) associated with NSAIDs are unknown. This study aimed to assess the risk factors of SBB in chronic NSAIDs users. Methods We retro...

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Bibliographic Details
Published in:Journal of digestive diseases 2015-09, Vol.16 (9), p.499-504
Main Authors: Cho, Kyu-Man, Park, Seon-Young, Chung, Jin Ook, Jun, Chung-Hwan, Kim, Tae-Jong, Son, Dong-Jun, Kim, Ban-Suk, Park, Chang-Hwan, Kim, Hyun-Soo, Choi, Sung-Kyu, Rew, Jong-Sun
Format: Article
Language:English
Subjects:
Aged
Alanine - analogs & derivatives
Alanine - therapeutic use
anti-inflammatory agents
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anti-Ulcer Agents - therapeutic use
antiplatelet agents
bleeding
Capsule Endoscopy
Cardiovascular disease
Confidence intervals
coronary artery disease
Coronary Artery Disease - epidemiology
Coronary vessels
Female
Gastrointestinal Hemorrhage - chemically induced
Gastrointestinal Hemorrhage - diagnosis
Gastrointestinal Hemorrhage - epidemiology
Health risk assessment
Humans
Incidence
Intestine, Small
Male
Middle Aged
non-steroidal
Nonsteroidal anti-inflammatory drugs
Platelet Aggregation Inhibitors - therapeutic use
Pyridines - therapeutic use
Quinolones - therapeutic use
Retrospective Studies
Risk Factors
small intestine
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Summary:Objective The incidence of nonsteroidal anti‐inflammatory drugs (NSAIDs)‐induced enteropathy is currently increasing. However, the predictors of small bowel bleeding (SBB) associated with NSAIDs are unknown. This study aimed to assess the risk factors of SBB in chronic NSAIDs users. Methods We retrospectively compared the medical records of 147 patients receiving NSAIDs in a tertiary‐care setting (31 with SBB and 116 without previous bleeding events) and analyzed the predictors of SBB. Results In total, 31 patients underwent video capsule endoscopy to detect SBB, 74.2% of whom showed the evidence of SBB. Non‐invasive treatment was performed in 90.3% of the patients. Multivariate logistic regression analysis revealed that the presence of coronary artery disease [adjusted odds ratio (aOR) 12.43, 95% confidence interval (CI) 1.19–130.34, P = 0.04], use of thienopyridine (aOR 16.93, 95% CI 3.78–75.72, P 
ISSN:1751-2972
1751-2980
DOI:10.1111/1751-2980.12269