Focal Adhesion Proteins α- and β-Parvin are Overexpressed in Human Colorectal Cancer and Correlate with Tumor Progression

This study aims to address the role of focal adhesion proteins α- and β-parvin in human colorectal carcinoma (CRC). Expression of α- and β-parvin was examined by immunohisto- chemistry and real-time RT-PCR in a series of human CRC. Parvins were overexpressed in CRC and their expression correlated si...

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Bibliographic Details
Published in:Cancer investigation 2015-09, Vol.33 (8), p.387-397
Main Authors: Bravou, Vasiliki, Antonacopoulou, Anna, Papanikolaou, Sofia, Nikou, Sofia, Lilis, Ioannis, Giannopoulou, Efstathia, Kalofonos, Haralabos P.
Format: Article
Language:English
Subjects:
Actinin - genetics
Actinin - metabolism
Adult
Aged
Aged, 80 and over
Alpha-parvin
beta Catenin - metabolism
Beta-parvin
Cadherins - metabolism
Colorectal cancer
Colorectal Neoplasms - genetics
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
EMT
Female
Focal adhesions
Gene Expression Regulation, Neoplastic
Humans
Integrin-linked kinase
Lymphatic Metastasis - genetics
Male
Microfilament Proteins - genetics
Microfilament Proteins - metabolism
Middle Aged
Protein-Serine-Threonine Kinases - metabolism
Proto-Oncogene Proteins c-akt - metabolism
Reference Values
Tumor progression
Young Adult
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Summary:This study aims to address the role of focal adhesion proteins α- and β-parvin in human colorectal carcinoma (CRC). Expression of α- and β-parvin was examined by immunohisto- chemistry and real-time RT-PCR in a series of human CRC. Parvins were overexpressed in CRC and their expression correlated significantly with tumor invasion, lymph node metastasis, and disease stage. A significant positive correlation of parvins protein expression with overexpression of integrin-linked kinase, p-AKT, and nuclear β-catenin, as well as with downregulation of E-cadherin was also observed. In conclusion, overexpression of α- and β-parvin seems to be implicated in human colorectal cancer progression.
ISSN:0735-7907
1532-4192
DOI:10.3109/07357907.2015.1047508