The B-cell antigen receptor integrates adaptive and innate immune signals

B cells respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or pathogen-associated molecular patterns are delivered. We show that the proliferative response of B cells to the latter stimuli is controlled by BCR-depende...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2015-09, Vol.112 (39), p.12145-12150
Main Authors: Otipoby, Kevin L., Waisman, Ari, Derudder, Emmanuel, Srinivasan, Lakshmi, Franklin, Andrew, Rajewsky, Klaus
Format: Article
Language:English
Subjects:
Adaptive Immunity - immunology
Animals
Antigens
Biological Sciences
Biosynthesis
Cell Proliferation - physiology
Cell Survival - immunology
Cells, Cultured
DNA Primers - genetics
Electrophoretic Mobility Shift Assay
Flow Cytometry
Immune response
Immunity, Innate - immunology
Immunoblotting
Immunology
Kinases
Mice
Models, Immunological
Phosphatidylinositol 3-Kinases - metabolism
Real-Time Polymerase Chain Reaction
Receptors, Antigen, B-Cell - immunology
Signal transduction
Signal Transduction - immunology
T cell receptors
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Summary:B cells respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or pathogen-associated molecular patterns are delivered. We show that the proliferative response of B cells to the latter stimuli is controlled by BCR-dependent activation of phosphoinositidyl 3-kinase (PI-3K) signaling. Glycogen synthase kinase 3β and Foxo1 are two PI-3K-regulated targets that play important roles, but to different extents, depending on the specific mitogen. These results suggest a model for integrating signals from the innate and the adaptive immune systems in the control of the B-cell immune response.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1516428112