Anterior mediastinal solid tumours in adults: characterisation using dynamic contrast-enhanced MRI, diffusion-weighted MRI, and FDG-PET/CT

Aim To find significant parameters to characterise anterior mediastinal solid tumours in adults using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), diffusion-weighted MRI (DWI), and combined 2-[18 F]-fluoro-2-deoxy- d- glucose positron-emission tomography/computed tomography (FDG-P...

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Bibliographic Details
Published in:Clinical radiology 2015-11, Vol.70 (11), p.1289-1298
Main Authors: Yabuuchi, H, Matsuo, Y, Abe, K, Baba, S, Sunami, S, Kamitani, T, Yonezawa, M, Yamasaki, Y, Kawanami, S, Nagao, M, Okamoto, T, Nakamura, K, Yamamoto, H, Sasaki, M, Honda, H
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Diffusion Magnetic Resonance Imaging - methods
Female
Fluorodeoxyglucose F18
Humans
Lymphoma - pathology
Magnetic Resonance Imaging - methods
Male
Mediastinal Neoplasms - pathology
Middle Aged
Multimodal Imaging - methods
Neoplasms, Germ Cell and Embryonal - pathology
Neoplasms, Glandular and Epithelial - pathology
Positron-Emission Tomography - methods
Prospective Studies
Radiology
Radiopharmaceuticals
ROC Curve
Sensitivity and Specificity
Thymoma - pathology
Thymus Neoplasms - pathology
Tomography, X-Ray Computed - methods
Young Adult
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Summary:Aim To find significant parameters to characterise anterior mediastinal solid tumours in adults using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), diffusion-weighted MRI (DWI), and combined 2-[18 F]-fluoro-2-deoxy- d- glucose positron-emission tomography/computed tomography (FDG-PET/CT). Materials and methods Forty-eight histologically confirmed anterior mediastinal solid tumours in 48 patients (24 men, 24 women; age range 21–83 years, mean 50.7 years) were examined. The parameters analysed were maximal diameter, presence of capsule/septa on T2-weighted images, time–signal intensity curves (TICs), apparent diffusion coefficient (ADC), and maximum standardised uptake value (SUVmax ). Also examined was whether any differences between histological types could be seen in these parameters. In a validation study, 42 anterior mediastinal solid tumours in 42 patients were examined consecutively. Results The washout pattern on TIC was seen only in thymic epithelial tumours (20/32). SUVmax of lymphoma (mean, 17.9), malignant germ cell tumours (14.2), and thymic carcinomas (15.6) were significantly higher than that of thymomas (6.1). The mean maximal diameter of thymic epithelial tumours was significantly smaller than that of lymphomas ( p
ISSN:0009-9260
1365-229X
DOI:10.1016/j.crad.2015.07.004