Preoperative Serum Prostate-Specific Antigen Levels Vary According to the Topographical Distribution of Prostate Cancer in Prostatectomy Specimens

Objective To evaluate whether the spatial distribution of prostate cancer (PCa) influences the concentration of prostate-specific antigen (PSA). Methods An observational prospective study was performed in 775 consecutive men with preoperative PSA levels ≤20 ng/mL who underwent radical prostatectomy...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2015-10, Vol.86 (4), p.798-804
Main Authors: Eminaga, Okyaz, Hinkelammert, Reemt, Abbas, Mahmoud, Wötzel, Fabian, Eltze, Elke, Bettendorf, Olaf, Boegemann, Martin, Semjonow, Axel
Format: Article
Language:English
Subjects:
Biopsy
Humans
Male
Middle Aged
Neoplasm Grading
Preoperative Period
Prognosis
Prospective Studies
Prostate - pathology
Prostate-Specific Antigen - blood
Prostatectomy
Prostatic Neoplasms - blood
Prostatic Neoplasms - pathology
Prostatic Neoplasms - surgery
Urology
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Summary:Objective To evaluate whether the spatial distribution of prostate cancer (PCa) influences the concentration of prostate-specific antigen (PSA). Methods An observational prospective study was performed in 775 consecutive men with preoperative PSA levels ≤20 ng/mL who underwent radical prostatectomy for organ-confined PCa. We evaluated prostate specimens using a cMDX-based map model of the prostate and determined the prostate volume, number of cancer foci, relative tumor volume, Gleason score, zone of origin, localization, and pathologic stage after stratification according to PSA levels categorized into 3 groups: 
ISSN:0090-4295
1527-9995
DOI:10.1016/j.urology.2015.07.029