Origin of methicillin-resistant Staphylococcus aureus health care-associated infections: Evaluation of the role of anterior nares

Methicillin-resistant Staphylococcus aureus (MRSA) health care-associated infections (HAIs) are a cause of extended hospitalizations and escalating health care costs. We typed 49 MRSA HAIs and their corresponding admission nasal MRSA isolates to determine strain-relatedness and better define the rol...

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Bibliographic Details
Published in:American journal of infection control 2015-10, Vol.43 (10), p.1125-1127
Main Authors: Jinadatha, Chetan, MD, MPH, Hussain, Zehra, DO, MPH, Erickson, Timothy A., BS, Villamaria, Frank C., MPH, Copeland, Laurel A., PhD, Huber, Thomas W., PhD
Format: Article
Language:English
Subjects:
Adult
Aged
Antibiotics
Contact isolation
Cross Infection - microbiology
Disease control
Drug resistance
Female
Genotyping by rep sequencing
Humans
Infection Control
Infectious Disease
Male
Methicillin-Resistant Staphylococcus aureus - classification
Methicillin-Resistant Staphylococcus aureus - genetics
Methicillin-Resistant Staphylococcus aureus - isolation & purification
Middle Aged
Molecular Epidemiology
Molecular Typing
MRSA
Nasal Mucosa - microbiology
Nasal swabbing
Nosocomial infections
Polymerase chain reaction
Retrospective Studies
Staphylococcal Infections - microbiology
Staphylococcus infections
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Summary:Methicillin-resistant Staphylococcus aureus (MRSA) health care-associated infections (HAIs) are a cause of extended hospitalizations and escalating health care costs. We typed 49 MRSA HAIs and their corresponding admission nasal MRSA isolates to determine strain-relatedness and better define the role of anterior nares in the causation of HAI and the value of decolonization. Based on repetitive extragenic palindromic sequencing polymerase chain reaction results, the majority of our patients possibly acquired MRSA HAI from nonnasal sources (36 out of 49; 74%). Among the remaining patients (13 out of 49; 26%) the nasal and clinical HAI isolates matched, indicating potential benefit of decolonization among this subsegment of patients. These findings may be relevant to institutions such as Veterans Health Administration hospitals that already have universal screening programs but are looking at ways to further reduce MRSA HAI incidence.
ISSN:0196-6553
1527-3296
DOI:10.1016/j.ajic.2015.05.026