A comparison between the conventional manual ROI method and an automatic algorithm for semiquantitative analysis of SPECT studies

In this study, the performance of a free software for automatic segmentation of striatal SPECT brain studies (BasGanV2 – www.aimn.it) and a standard manual Region Of Interest (ROI) method were compared. The anthropomorphic Alderson RSD phantom, filled with solutions at different concentration of 123...

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Bibliographic Details
Published in:Journal of physics. Conference series 2011-09, Vol.317 (1), p.012004-4
Main Authors: Pagan, L, Tranfaglia, C, Galli, S, Lucchi, G, Novi, B, Fagioli, G, Guidarelli, G
Format: Article
Language:English
Subjects:
Algorithms
Automation
Availability
Computer programs
Counting
Image filters
Image reconstruction
Image segmentation
Manuals
Physics
Software
Uptakes
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Summary:In this study, the performance of a free software for automatic segmentation of striatal SPECT brain studies (BasGanV2 – www.aimn.it) and a standard manual Region Of Interest (ROI) method were compared. The anthropomorphic Alderson RSD phantom, filled with solutions at different concentration of 123I-FP-CIT with Caudate-Putamen to Background ratios between 1 and 8.7 and Caudate to Putamen ratios between 1 and 2, was imaged on a Philips-Irix triple head gamma camera. Images were reconstructed using filtered back-projection and processed with both BasGanV2, that provides normalized striatal uptake values on volumetric anatomical ROIs, and a manual method, based on average counts per voxel in ROIs drawn in a three-slice section. Caudate-Putamen/Background and Caudate/Putamen ratios obtained with the two methods were compared with true experimental ratios. Good correlation was found for each method; BasGanV2, however, has higher R index (BasGan Rmean 0.95, p < 0.001) than the ROI method (Rmean 0.89, p < 0.005). The results obtained suggest that this new software can be suitable in daily practice, being an accurate, simple, fully automatic and reproducible method of semiquantitative analysis of 123I-FP-CIT SPECT data with, moreover, the advantage of the availability of a control subject's database.
ISSN:1742-6596
1742-6588
1742-6596
DOI:10.1088/1742-6596/317/1/012004