Copper-Catalyzed Aryltrifluoromethylation of N-Phenylcinnamamides: Access to Trifluoromethylated 3,4-Dihydroquinolin-2(1 H)-ones

A method for copper‐catalyzed aryltrifluoromethylation of N‐phenylcinnamamides is reported. This method provides a straightforward route to a variety of CF3‐containing 3,4‐dihydroquinolin‐2(1 H)‐ones with excellent regioselectivity and diastereoselectivity.

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2015-08, Vol.357 (11), p.2464-2468
Main Authors: Wang, Qiang, Han, Guifang, Liu, Yuxiu, Wang, Qingmin
Format: Article
Language:English
Subjects:
aryltrifluoromethylation
Catalysis
copper
diastereoselectivity
regioselectivity
Synthesis
Togni's reagent
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Description
Summary:A method for copper‐catalyzed aryltrifluoromethylation of N‐phenylcinnamamides is reported. This method provides a straightforward route to a variety of CF3‐containing 3,4‐dihydroquinolin‐2(1 H)‐ones with excellent regioselectivity and diastereoselectivity.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201500261