Palladium-catalyzed oxalyl amide assisted direct ortho-alkynylation of arylalkylamine derivatives at δ and ε positions

Palladium-catalyzed oxalyl amide directed ortho-alkynylation of arylalkylamine derivatives is reported for the first time. A wide variety of β-arylethamine and γ-arylpropamine derivatives are compatible with this protocol. This method provides a general means to synthesize substituted alkynylarylalk...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-08, Vol.51 (60), p.12103-12106
Main Authors: Guan, Mingyu, Chen, Changpeng, Zhang, Jingyu, Zeng, Runsheng, Zhao, Yingsheng
Format: Article
Language:English
Subjects:
Amides
Compatibility
Derivatives
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Summary:Palladium-catalyzed oxalyl amide directed ortho-alkynylation of arylalkylamine derivatives is reported for the first time. A wide variety of β-arylethamine and γ-arylpropamine derivatives are compatible with this protocol. This method provides a general means to synthesize substituted alkynylarylalkylamine derivatives, highlighting the ability of oxalyl amide in promoting C-H functionalization at unique δ and ε positions.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc04390e