Electrocatalytic boost up of epinephrine and its simultaneous resolution in the presence of serotonin and folic acid at poly(serine)/multi-walled carbon nanotubes composite modified electrode: A voltammetric study

• Published in: Materials Science & Engineering C 2015-11, Vol.56, p.57-65
• Main Authors: Narayana, P.V., Madhusudana Reddy, T., Gopal, P., Mohan Reddy, M., Ramakrishna Naidu, G.
• Format: Article
• Language: English
• Subjects: Biosensing Techniques - methods; Catalysis; Dielectric Spectroscopy - methods; Differential pulse voltammetry; Electrochemical impedance spectroscopy; Electrochemical Techniques - methods; Electrodes; Epinephrine; Epinephrine - chemistry; Folic acid; Folic Acid - chemistry; Glass - chemistry; Hydrogen-Ion Concentration; Limit of Detection; Multi wall carbon nanotubes; Multi-walled carbon nanotubes; Nanocomposite electrode; Nanocomposites - chemistry; Nanostructure; Nanotubes, Carbon - chemistry; Sensors; Serine - chemistry; Serotonin; Serotonin - chemistry; Simultaneous determination
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2015.06.011

The present paper describes the new strategy for the development of nanosensor based on dropcasting of multi-walled carbon nanotubes (MWCNTs) followed by electropolymerization of serine (ser) onto the glassy carbon electrode (GCE). The developed nanocomposite sensor was abbreviated as poly(ser)/MWCNTs/GCE and was characterized by using electrochemical impedance spectroscopy (EIS) technique. The EIS results confirmed the fast electron transfer rate at the surface of poly(ser)/MWCNTs/GCE. The proposed sensor exhibited good catalytic activity towards the sensing of epinephrine (EP) individually and simultaneously in the presence of serotonin (5-HT) and folic acid (FA) in 0.1M phosphate buffer solution (PBS) at pH7.0. The limit of detection (LOD) and limit of quantification (LOQ) of EP was found to be 6×10−7M and 2×10−6M respectively. The fabricated sensor showed excellent precision and accuracy with a relative standard deviation (RSD) of 4.86%. The proposed composite sensor was effectively applied towards the determination of EP in human blood serum and pharmaceutical injection sample. [Display omitted] •Poly(ser)/MWCNTs/GCE showed high sensitivity in the sensing of EP.•The sensor reduced the overpotential for oxidation of EP.•This electrode was successfully used for simultaneous sensing of EP, 5-HT and FA.•The electrode was effectively used for the determination of EP in real samples.