Real-Time High-Resolution Tandem Mass Spectrometry Identifies Furan Derivatives in Exhaled Breath

The identification of chemical compounds in exhaled human breath is promising in the search for new biomakers of diseases. However, the analytical techniques used nowadays are not capable of achieving a robust identification, especially in real-time analysis. In this work, we show that real-time hig...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2015-07, Vol.87 (13), p.6919-6924
Main Authors: García-Gómez, Diego, Bregy, Lukas, Barrios-Collado, César, Vidal-de-Miguel, Guillermo, Zenobi, Renato
Format: Article
Language:English
Subjects:
Biomarkers
Breath Tests
Chemical compounds
Chromatography, High Pressure Liquid
Derivatives
Furans
Furans - analysis
Human
Mass spectrometry
Mathematical analysis
Real time
Respiration
Tandem Mass Spectrometry - methods
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Summary:The identification of chemical compounds in exhaled human breath is promising in the search for new biomakers of diseases. However, the analytical techniques used nowadays are not capable of achieving a robust identification, especially in real-time analysis. In this work, we show that real-time high-resolution tandem mass spectrometry (HRMS/MS) is suitable for the identification of biomarkers in exhaled breath. Using this approach, we identified a number of furan derivatives, compounds found in the exhalome whose nature and origin are not yet clearly understood. It is also shown that the combination of HRMS/MS with UHPLC allowed not only the identification of the furan derivatives but also the proper separation of their isomeric forms.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.5b01509