Selective photosensitization through an AND logic response: optimization of the pH and glutathione response of activatable photosensitizers

A series of pH and GSH responsive photosensitizers were designed and synthesized. pKa values were optimized by adjusting the inductive contribution of substituents to reach a pH range (6.0-7.4) relevant to the tumour microenvironment. pH-Activatable behaviour and redox mediated release of the quench...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-08, Vol.51 (61), p.12258-12261
Main Authors: Erbas-Cakmak, Sundus, Cakmak, Fatma Pir, Topel, Seda Demirel, Uyar, Taha Bilal, Akkaya, Engin U
Format: Article
Language:English
Subjects:
Adjustment
Aqueous solutions
Construction
Logic
Operators
Optimization
Tumours
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Summary:A series of pH and GSH responsive photosensitizers were designed and synthesized. pKa values were optimized by adjusting the inductive contribution of substituents to reach a pH range (6.0-7.4) relevant to the tumour microenvironment. pH-Activatable behaviour and redox mediated release of the quencher from the PS by GSH allow the construction of an AND logic operator for selective photodynamic action in aqueous solutions.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc01261a