The effect of molecular structure on the anticancer drug release rate from prodrug nanoparticles

The controlled release of an anticancer agent from drug nanoparticles could be achieved by varying the linker length of dimeric compounds as prodrug. Notably, the cytotoxicity of the cancer cells was closely related to the release rate of drug compounds. This strategy will lead to the establishment...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-08, Vol.51 (64), p.12835-12838
Main Authors: Ikuta, Yoshikazu, Koseki, Yoshitaka, Onodera, Tsunenobu, Oikawa, Hidetoshi, Kasai, Hitoshi
Format: Article
Language:English
Subjects:
Anticancer properties
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cell Line, Tumor
Cell Survival - drug effects
Chemical compounds
Controlled release
Dicarboxylic Acids - chemistry
Dimerization
Drug Carriers - chemistry
Drug delivery systems
Drug Liberation
Drugs
Humans
Molecular structure
Nanoparticles
Nanoparticles - chemistry
Podophyllotoxin - chemistry
Prodrugs - chemistry
Strategy
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Summary:The controlled release of an anticancer agent from drug nanoparticles could be achieved by varying the linker length of dimeric compounds as prodrug. Notably, the cytotoxicity of the cancer cells was closely related to the release rate of drug compounds. This strategy will lead to the establishment of the novel delivery system using drug nanoparticles.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc04164c