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Common fragile site expression and genetic predisposition to breast cancer
The expression of common fragile sites induced by aphidicolin and caffeine was evaluated on prometaphase obtained from the peripheral blood lymphocytes of 35 women with breast cancer, their 35 clinically healthy female family members, and 20 sex‐ and age‐matched normal controls. As a result of the c...
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| Published in: | Teratogenesis, carcinogenesis, and mutagenesis carcinogenesis, and mutagenesis, 1998, Vol.18 (6), p.279-291 |
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| Language: | English |
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| container_end_page | 291 |
| container_issue | 6 |
| container_start_page | 279 |
| container_title | Teratogenesis, carcinogenesis, and mutagenesis |
| container_volume | 18 |
| creator | Çeçener, Gülşah Egeli, Ünal Taşdelen, Ismet Tunca, Berrin Duman, Hakan Kizil, Ayhan |
| description | The expression of common fragile sites induced by aphidicolin and caffeine was evaluated on prometaphase obtained from the peripheral blood lymphocytes of 35 women with breast cancer, their 35 clinically healthy female family members, and 20 sex‐ and age‐matched normal controls. As a result of the cytogenetic and statistical evaluation, the number of damaged cells, chromosomal aberrations, and expression frequencies of fragile sites detected in patients with breast cancer and their first‐degree relatives were found to be significantly higher than those in the control group. Our findings indicate an increased genetic instability in women with breast carcinomas and their relatives. Therefore, fragile sites may be used as a reliable marker for defining genetic susceptibility to cancer in general. Teratogenesis Carcinog. Mutagen. 18:279–291, 1998. © 1998 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1520-6866(1998)18:6<279::AID-TCM2>3.0.CO;2-U |
| format | article |
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As a result of the cytogenetic and statistical evaluation, the number of damaged cells, chromosomal aberrations, and expression frequencies of fragile sites detected in patients with breast cancer and their first‐degree relatives were found to be significantly higher than those in the control group. Our findings indicate an increased genetic instability in women with breast carcinomas and their relatives. Therefore, fragile sites may be used as a reliable marker for defining genetic susceptibility to cancer in general. Teratogenesis Carcinog. 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Obstetrics ; Humans ; Lymphocytes - ultrastructure ; Mammary gland diseases ; Medical sciences ; Pedigree ; Risk Factors ; Tumors</subject><ispartof>Teratogenesis, carcinogenesis, and mutagenesis, 1998, Vol.18 (6), p.279-291</ispartof><rights>Copyright © 1998 Wiley‐Liss, Inc.</rights><rights>1999 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1736955$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10052563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Çeçener, Gülşah</creatorcontrib><creatorcontrib>Egeli, Ünal</creatorcontrib><creatorcontrib>Taşdelen, Ismet</creatorcontrib><creatorcontrib>Tunca, Berrin</creatorcontrib><creatorcontrib>Duman, Hakan</creatorcontrib><creatorcontrib>Kizil, Ayhan</creatorcontrib><title>Common fragile site expression and genetic predisposition to breast cancer</title><title>Teratogenesis, carcinogenesis, and mutagenesis</title><addtitle>Teratog. Carcinog. Mutagen</addtitle><description>The expression of common fragile sites induced by aphidicolin and caffeine was evaluated on prometaphase obtained from the peripheral blood lymphocytes of 35 women with breast cancer, their 35 clinically healthy female family members, and 20 sex‐ and age‐matched normal controls. As a result of the cytogenetic and statistical evaluation, the number of damaged cells, chromosomal aberrations, and expression frequencies of fragile sites detected in patients with breast cancer and their first‐degree relatives were found to be significantly higher than those in the control group. Our findings indicate an increased genetic instability in women with breast carcinomas and their relatives. Therefore, fragile sites may be used as a reliable marker for defining genetic susceptibility to cancer in general. Teratogenesis Carcinog. Mutagen. 18:279–291, 1998. © 1998 Wiley‐Liss, Inc.</description><subject>aphidicolin</subject><subject>Aphidicolin - toxicity</subject><subject>Biological and medical sciences</subject><subject>breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - prevention & control</subject><subject>caffeine</subject><subject>Caffeine - toxicity</subject><subject>chromosomal abnormalities</subject><subject>Chromosome Aberrations</subject><subject>Chromosome Fragile Sites</subject><subject>Chromosome Fragility - genetics</subject><subject>Female</subject><subject>fragile sites</subject><subject>Genetic Markers</subject><subject>Genetic Predisposition to Disease</subject><subject>genetic susceptibility</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Lymphocytes - ultrastructure</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Pedigree</subject><subject>Risk Factors</subject><subject>Tumors</subject><issn>0270-3211</issn><issn>1520-6866</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNp9kF1v0zAUhi0EYt3gL6BcILRdpPjYsR0XhDQFNooGFbCCxM2R6zhTRj46OxXbv8ehVUECcWX5-NHr9zyEzIBOgVL2_PjzvJifgGA0lbmUx6B1fgL5TL5kSs9mp_PX6WXxnr3iUzotFi9YurxHJnv8PplQpmjKGcABOQzhmlKgAOwhOYjxggnJJ-Rd0bdt3yWVN1d145JQDy5xt2vvQqjj3HRlcuU6N9Q2icOyDus-MuPT0Ccr70wYEms66_wj8qAyTXCPd-cRWZ69uSzepheL83lxepFaniuWOimVBLFiJfBsJcAqQblSJROUroBqVSrNGasyBVxWlulMG10KwWWe0cpofkSebXPXvr_ZuDBgWwfrmsZ0rt8EBAW5lpmK4KctaH0fgncVrn3dGn-HQHE0jDgaxlEZjspwNIyQo8RoGDEaxtEwcqRYLJDhMoY-2f2-WbWu_CNyqzQCT3eACdY0UWxn6_CbU1zquM2-3I-o_e6vZv8t9o9ev-4xNN2G1mFwt_tQ47-jVFwJ_PrhHKOebx_hrMAv_Cduga-G</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>Çeçener, Gülşah</creator><creator>Egeli, Ünal</creator><creator>Taşdelen, Ismet</creator><creator>Tunca, Berrin</creator><creator>Duman, Hakan</creator><creator>Kizil, Ayhan</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>1998</creationdate><title>Common fragile site expression and genetic predisposition to breast cancer</title><author>Çeçener, Gülşah ; Egeli, Ünal ; Taşdelen, Ismet ; Tunca, Berrin ; Duman, Hakan ; Kizil, Ayhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3872-e667615b2d134b51c750377d2500b1097d79322f47136fc2949a9d5536840fa93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>aphidicolin</topic><topic>Aphidicolin - toxicity</topic><topic>Biological and medical sciences</topic><topic>breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - prevention & control</topic><topic>caffeine</topic><topic>Caffeine - toxicity</topic><topic>chromosomal abnormalities</topic><topic>Chromosome Aberrations</topic><topic>Chromosome Fragile Sites</topic><topic>Chromosome Fragility - genetics</topic><topic>Female</topic><topic>fragile sites</topic><topic>Genetic Markers</topic><topic>Genetic Predisposition to Disease</topic><topic>genetic susceptibility</topic><topic>Gynecology. 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| ispartof | Teratogenesis, carcinogenesis, and mutagenesis, 1998, Vol.18 (6), p.279-291 |
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| language | eng |
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| subjects | aphidicolin Aphidicolin - toxicity Biological and medical sciences breast cancer Breast Neoplasms - genetics Breast Neoplasms - prevention & control caffeine Caffeine - toxicity chromosomal abnormalities Chromosome Aberrations Chromosome Fragile Sites Chromosome Fragility - genetics Female fragile sites Genetic Markers Genetic Predisposition to Disease genetic susceptibility Gynecology. Andrology. Obstetrics Humans Lymphocytes - ultrastructure Mammary gland diseases Medical sciences Pedigree Risk Factors Tumors |
| title | Common fragile site expression and genetic predisposition to breast cancer |
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