Oxidative stress inhibition and oxidant activity by fibrous clays

Fibrous clays (sepiolite, palygorskite) are produced at 1.2m tonnes per year and have a wide range of industrial applications needing to replace long-fibre length asbestos. However, information on the beneficial effects of fibrous clays on health remains scarce. This paper reports on the effect of s...

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Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2015-09, Vol.133, p.32-35
Main Authors: Cervini-Silva, Javiera, Nieto-Camacho, Antonio, Gómez-Vidales, Virginia
Format: Article
Language:English
Subjects:
Aluminum Silicates
Biomaterials
Clays
Hydroxyl radicals
Inhibition
Lipid Peroxidation - drug effects
Oxidants
Oxidants - pharmacology
Oxidative Stress
Oxidizing agents
Sepiolite
Silanol groups
Stresses
Surface chemistry
Surface-controlled
Tetrahedron-inversion sites
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Summary:Fibrous clays (sepiolite, palygorskite) are produced at 1.2m tonnes per year and have a wide range of industrial applications needing to replace long-fibre length asbestos. However, information on the beneficial effects of fibrous clays on health remains scarce. This paper reports on the effect of sepiolite (Vallecas, Spain) and palygorskite (Torrejón El Rubio, Spain) on cell damage via oxidative stress (determined as the progress of lipid peroxidation, LP). The extent of LP was assessed using the Thiobarbituric Acid Reactive Substances assay. The oxidant activity by fibrous clays was quantified using Electron-Paramagnetic Resonance. Sepiolite and palygorskite inhibited LP, whereby corresponding IC50 values were 6557±1024 and 4250±289μgmL−1. As evidenced by dose-response experiments LP inhibition by palygorskite was surface-controlled. Fibrous clay surfaces did not stabilize HO species, except for suspensions containing 5000μgmL−1. A strong oxidant (or weak anti-oxidant) activity favours the inhibition of LP by fibrous clays.
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2015.05.042