Antigen‐specific antibody responses in lupus patients following immunization

• Published in: Arthritis and rheumatism 1998-10, Vol.41 (10), p.1828-1834
• Main Authors: Battafarano, Daniel F., Battafarano, Nicholas J., Larsen, Lawrence, Dyer, P. Dennis, Older, Steven A., Muehlbauer, S., Hoyt, A., Lima, J., Goodman, David, Lieberman, Michael, Enzenauer, Raymond J.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Antibody Formation - drug effects; Azathioprine - pharmacology; Bacterial Vaccines - administration & dosage; Biological and medical sciences; Cyclophosphamide - pharmacology; Epitopes - immunology; Haemophilus Vaccines - administration & dosage; Humans; Immunization - adverse effects; Lupus Erythematosus, Systemic - immunology; Medical sciences; Middle Aged; Prednisone - pharmacology; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Streptococcus pneumoniae - immunology; Tetanus Toxoid - administration & dosage
• ISSN: 0004-3591; 1529-0131
• DOI: 10.1002/1529-0131(199810)41:10<1828::AID-ART15>3.0.CO;2-T

Objective To determine the safety and efficacy of 3 clinically relevant vaccines in patients with systemic lupus erythematosus (SLE). Methods We studied 73 consecutive SLE patients immunized with pneumococcal, tetanus toxoid (TT), and Haemophilus influenzae type B (HIB) vaccines. Patients were evaluated preimmunization and 12 weeks postimmunization for disease activity and immunization side effects. Results Eighty‐four percent of the SLE patients developed a 4‐fold titer increase in response to at least 1 vaccine, with 51% developing a 2‐fold titer increase with all 3 vaccines. The majority of SLE patients developed protective levels of antibody to TT (90%) and HIB (88%). Although protective antibody levels could not be determined for pneumococcus, almost half of the patients (47%) developed a 4‐fold antibody response. There was a trend toward a lower antibody response in patients with active disease treated with immunosuppressive therapy. Overall lupus disease activity was unaffected by immunization. Conclusion Immunization is safe in SLE patients, with the overwhelming majority developing protective antibody levels. Therefore, SLE patients should receive immunizations according to the recommendations of the Centers for Disease Control and Prevention and the Immunization Practices Advisory Committee.