Randomized trial comparing the velocities of the antihypertensive effects on home blood pressure of candesartan and candesartan with hydrochlorothiazide

We aimed to evaluate the hypotensive effect and the time to attain the maximal antihypertensive effect (stabilization time) of 8 mg candesartan/6.25 mg hydrochlorothiazide (HCTZ) combination therapy (combination regimen) and therapy with an increased candesartan dose (12 mg; maximum dose regimen) us...

Full description

Saved in:
Bibliographic Details
Published in:Hypertension research 2015-10, Vol.38 (10), p.701-707
Main Authors: Hosaka, Miki, Metoki, Hirohito, Satoh, Michihiro, Ohkubo, Takayoshi, Asayama, Kei, Kikuya, Masahiro, Inoue, Ryusuke, Obara, Taku, Hirose, Takuo, Imai, Yutaka
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Angiotensin II Type 1 Receptor Blockers - therapeutic use
Antihypertensive Agents - therapeutic use
Antihypertensives
Antiretroviral drugs
Benzimidazoles - therapeutic use
Blood Pressure
Diuretics - therapeutic use
Drug Therapy, Combination
Female
Humans
Hydrochlorothiazide - therapeutic use
Hypertension
Hypertension - drug therapy
Male
Middle Aged
Pressure measurement
Prospective Studies
Tetrazoles - therapeutic use
Treatment Outcome
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We aimed to evaluate the hypotensive effect and the time to attain the maximal antihypertensive effect (stabilization time) of 8 mg candesartan/6.25 mg hydrochlorothiazide (HCTZ) combination therapy (combination regimen) and therapy with an increased candesartan dose (12 mg; maximum dose regimen) using home blood pressure (BP) measurements. A prospective, multicenter, open-label, randomized, comparative trial was conducted. Essential hypertensive patients who failed to achieve adequate BP control (systolic BP (SBP) ⩽ 135 mm Hg) on 8 mg candesartan alone were randomized to two groups: the combination regimen (n=103) and the maximum dose regimen (n=103). Home morning SBP reduction at 8 weeks after randomization was 11.4 ± 1.3 mm Hg in the combination regimen and 7.8 ± 1 .2 mm Hg in the maximum dose regimen. The combination regimen provided additional reduction of 4.0 mm Hg (95% confidence interval (CI): 0.8-7.2 mm Hg, P=0.01) in home morning SBP over the maximum dose regimen at 8 weeks after randomization. The maximal antihypertensive effect and stabilization time for home SBP were 9.4 mm Hg and 37.1 days (P0.2). The rate of achieving target BP (home morning SBP
ISSN:0916-9636
1348-4214
DOI:10.1038/hr.2015.64