Mucin–drugs interaction: The case of theophylline, prednisolone and cephalexin

[Display omitted] The binding of mucin with three commercially available drugs (theophylline, cephalexin and prednisolone) belonging to different pharmaceutical classes was investigated. The studied drugs are normally used to treat the symptomatology of cystic fibrosis. The interaction between drugs...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2015-10, Vol.23 (20), p.6581-6586
Main Authors: Pontremoli, Carlotta, Barbero, Nadia, Viscardi, Guido, Visentin, Sonja
Format: Article
Language:English
Subjects:
Animals
Binding Sites
Cephalexin - chemistry
Drugs
FRET
Interaction
Molecular Structure
Mucin
Mucins - chemistry
Prednisolone - chemistry
Spectrometry, Fluorescence
Spectrophotometry, Ultraviolet
Stomach - chemistry
Swine
Theophylline - chemistry
Thermodynamics
UV–Vis and fluorescence spectroscopy
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Summary:[Display omitted] The binding of mucin with three commercially available drugs (theophylline, cephalexin and prednisolone) belonging to different pharmaceutical classes was investigated. The studied drugs are normally used to treat the symptomatology of cystic fibrosis. The interaction between drugs and mucin has been investigated using fluorescence and UV–Vis absorption spectroscopy; quenching mechanism, binding constants, binding sites, thermodynamic parameters and binding distance of the interaction were obtained.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2015.09.021