Erythrocyte and Biochemical Abnormalities as Diagnostic Markers in Dogs With Hemangiosarcoma Related Hemoabdomen

OBJECTIVE: To investigate: 1) acanthocytosis and presence of acanthocytes in peritoneal fluid as a diagnostic marker for hemangiosarcoma (HSA) in dogs with non‐traumatic hemoabdomen; and 2) the association between other erythrocyte, biochemical, and hematologic abnormalities as a mean of differentia...

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Bibliographic Details
Published in:Veterinary surgery 2015-10, Vol.44 (7), p.852-857
Main Authors: Wong, Richard W., Gonsalves, Mishka N., Huber, Michael L., Rich, Lon, Strom, Adam
Format: Article
Language:English
Subjects:
Abdominal Neoplasms - physiopathology
Abdominal Neoplasms - veterinary
Acanthocytes - metabolism
Animal diseases
Animals
Ascitic Fluid - pathology
Biochemistry
Biomarkers
Biomarkers - analysis
Blood Chemical Analysis - veterinary
Dog Diseases - pathology
Dogs
Double-Blind Method
Erythrocytes
Female
Hemangiosarcoma - diagnosis
Hemangiosarcoma - veterinary
Hemorrhage - pathology
Hemorrhage - physiopathology
Hemorrhage - veterinary
Male
Prospective Studies
Veterinary medicine
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Summary:OBJECTIVE: To investigate: 1) acanthocytosis and presence of acanthocytes in peritoneal fluid as a diagnostic marker for hemangiosarcoma (HSA) in dogs with non‐traumatic hemoabdomen; and 2) the association between other erythrocyte, biochemical, and hematologic abnormalities as a mean of differentiating HSA from other disease. STUDY DESIGN: Prospective double‐blinded cohort study. ANIMALS: Dogs (n = 40) with non‐traumatic hemoabdomen. METHODS: Dogs diagnosed with hemoabdomen (January 2012 to May 2013) had cytologic evaluation of abdominal effusion and peripheral blood smears. Peripheral blood CBC, PT, and aPTT, as well as blood and effusion acanthocytes, keratocytes, schistocytes, lactate, glucose, PCV, and TP results were compared using the paired t‐test or Fisher's exact test. Based on histologic confirmation of HSA, dogs were divided into 2 groups (HSA, non‐HSA) and variables compared. RESULTS: There was no significant difference in erythrocyte morphology in abdominal effusion or peripheral blood between dogs with HSA or non‐HSA related hemoabdomen. Platelet concentration and peripheral blood PCV were significantly lower in the HSA group. CONCLUSIONS: A reliable preoperative biochemical or cytologic test to differentiate between HSA and non‐HSA related hemoabdomen was not identified.
ISSN:0161-3499
1532-950X
DOI:10.1111/vsu.12361