Epistasis in allelic expression at upper temperature tolerance QTL in rainbow trout

• Published in: Aquaculture 1999-03, Vol.173 (1), p.45-58
• Main Authors: Danzmann, Roy G., Jackson, Timothy R., M. Ferguson, Moira
• Format: Article
• Language: English
• Subjects: Animal aquaculture; Animal productions; Animals; Aquaculture; Biological and medical sciences; Brackish; CALOR; CARTE GENETIQUE; CHALEUR; Classical genetics, quantitative genetics, hybrids; Epistasis; Fish; Freshwater; Fundamental and applied biological sciences. Psychology; GENE INTERACTION; GENETIC MAPS; Genetics; Genetics of eukaryotes. Biological and molecular evolution; HEAT; HETEROSIS; INTERACCION DE GENES; INTERACTION GENIQUE; MAPAS GENETICOS; Marine; MICROSATELITES; MICROSATELLITE; MICROSATELLITES; ONCORHYNCHUS MYKISS; Outbreeding depression; Pisciculture; Rainbow trout; RESISTANCE A LA TEMPERATURE; RESISTENCIA A LA TEMPERATURA; Temperature; TEMPERATURE RESISTANCE; Vertebrata; Vertebrate aquaculture; VIGOR HIBRIDO; VIGUEUR HYBRIDE
• ISSN: 0044-8486; 1873-5622
• DOI: 10.1016/S0044-8486(98)00465-7

We have mapped the location of QTL affecting upper temperature tolerance in three backcross families of rainbow trout ( Oncorhynchus mykiss) derived from matings between an F 1 male (high (H)×low (L) temperature tolerance selected lines) and two H and one L line females using variation at 61 microsatellite loci. Physiological epistasis was observed among paternally inherited QTL alleles and this depended upon the genomic background in which the alleles were expressed. A marker allele associated with a QTL leading to enhanced thermal resistance in one background (either H or L) showed the opposite association in the other genomic background. These results suggest that the effectiveness of marker assisted selection (MAS) may be limited without prior knowledge of the performance characteristics of QTL alleles in different genomic backgrounds.