Virological analysis of inherited chromosomally integrated human herpesvirus‐6 in three hematopoietic stem cell transplant patients

We analyzed 3 hematopoietic stem cell transplant (HSCT) recipients with inherited chromosomally integrated human herpesvirus‐6 (inherited CIHHV‐6). Cases 1 (inherited CIHHV‐6A) and 2 (inherited CIHHV‐6B) were inherited CIHHV‐6 recipients. Case 3 received bone marrow from a donor with inherited CIHHV...

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Bibliographic Details
Published in:Transplant infectious disease 2015-10, Vol.17 (5), p.728-731
Main Authors: Miura, H., Kawamura, Y., Kudo, K., Ihira, M., Ohye, T., Kurahashi, H., Kawashima, N., Miyamura, K., Yoshida, N., Kato, K., Takahashi, Y., Kojima, S., Yoshikawa, T.
Format: Article
Language:English
Subjects:
Bone marrow
Child
Child, Preschool
DNA, Viral - isolation & purification
Female
Hematopoietic Stem Cell Transplantation
Herpesvirus 6, Human - genetics
Herpesvirus 6, Human - isolation & purification
HSCT
Humans
inherited CIHHV‐6
Male
reactivation
RT‐PCR
Stem cells
Transplants & implants
Virus Integration
Young Adult
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Summary:We analyzed 3 hematopoietic stem cell transplant (HSCT) recipients with inherited chromosomally integrated human herpesvirus‐6 (inherited CIHHV‐6). Cases 1 (inherited CIHHV‐6A) and 2 (inherited CIHHV‐6B) were inherited CIHHV‐6 recipients. Case 3 received bone marrow from a donor with inherited CIHHV‐6B. Following HSCT, HHV‐6B was isolated from Case 1. HHV‐6A and ‐6B messenger RNAs were detected in Cases 1 and 3.
ISSN:1398-2273
1399-3062
DOI:10.1111/tid.12419