HCV infection is associated with lower survival in simultaneous liver kidney transplant recipients in the United States

• Published in: Clinical transplantation 2015-10, Vol.29 (10), p.920-926
• Main Authors: Perumpail, Ryan B., Wong, Robert J., Scandling, John D., Ha, Le Dung, Todo, Tsuyoshi, Bonham, Clark A., Saab, Sammy, Younossi, Zobair M., Ahmed, Aijaz
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; End Stage Liver Disease - complications; End Stage Liver Disease - mortality; End Stage Liver Disease - surgery; End Stage Liver Disease - virology; Female; hepatitis C virus; Hepatitis C, Chronic - complications; Hepatitis C, Chronic - mortality; Humans; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - mortality; Kidney Failure, Chronic - surgery; Kidney Failure, Chronic - virology; Kidney Transplantation - mortality; Liver Transplantation - mortality; Male; Middle Aged; model for end-stage liver disease; Registries; Retrospective Studies; simultaneous liver kidney transplantation; Survival Analysis; Treatment Outcome; United States; UNOS/OPTN; Young Adult
• ISSN: 0902-0063; 1399-0012
• DOI: 10.1111/ctr.12598

Background The frequency of simultaneous liver kidney transplantation (SLKT) has been increasing over the past decade. Hepatitis C virus (HCV) infection is the most common indication for liver transplantation in the United States. Given the rising prevalence of HCV‐related SLKT, it is important to understand the impact of HCV in this patient population. Methods We conducted a retrospective cohort study using data from the United Network for Organ Sharing registry to assess adult patients undergoing SLKT in the United States from 2003 to 2012. Patient survival following SLKT was assessed using Kaplan–Meier methods and multivariate Cox proportional hazards models. Results Patients infected with non‐HCV have significantly lower survival following SLKT compared to non‐HCV patients at three (three‐yr survival: 71.0% vs. 78.9%, p