Regulatory effects of cytokine production in atopic allergic reaction by gammi-danguieumja

Gammi-danguieumja (GD) is clinically used in South Korea for treating atopic dermatitis. However, its effects in experimental models remain unknown. We investigated a possible effect of GD on cytokines production using human T cell line (MOLT-4) or human mast cell line. As a result, GD (0.01 mg/mL)-...

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Bibliographic Details
Published in:Inflammation 2004-10, Vol.28 (5), p.291-298
Main Authors: Na, Ho-Jeong, Shin, Hye-Young, Kim, Na-Hyung, Kwon, Mi-Won, Park, Eun-Jeong, Hong, Seung-Heon, Kim, Nam-Il, Kim, Hyung-Min
Format: Article
Language:English
Subjects:
Animals
Anti-Allergic Agents - pharmacology
Anti-Allergic Agents - toxicity
Calcimycin
Cell Line
Cell Survival
Cytokines - immunology
Drugs, Chinese Herbal - pharmacology
Drugs, Chinese Herbal - toxicity
Histamine Release - drug effects
Humans
Interferon-gamma - immunology
Interleukin-8 - immunology
Ionophores
Mast Cells - drug effects
Mast Cells - immunology
p-Methoxy-N-methylphenethylamine
Rats
Rats, Sprague-Dawley
T-Lymphocytes - drug effects
T-Lymphocytes - immunology
Tetradecanoylphorbol Acetate - analogs & derivatives
Tumor Necrosis Factor-alpha - immunology
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Summary:Gammi-danguieumja (GD) is clinically used in South Korea for treating atopic dermatitis. However, its effects in experimental models remain unknown. We investigated a possible effect of GD on cytokines production using human T cell line (MOLT-4) or human mast cell line. As a result, GD (0.01 mg/mL)-containing medium in stimulated culture supernatants increased IL-2 and IFN-gamma, and decreased IL-4 secretion in MOLT-4. GD (0.01-1 mg/mL)-containing medium in stimulated culture supernatants dose-dependently and significantly decreased IL-8, IL-13, and tumor necrosis factor-alpha secretion on the phorbol 12-myristate 13-acetate and A23187-stimulated HMC-1. In addition, GD inhibited histamine release from activated mast cells. These results suggest that GD contributes to the regulation of atopic allergic reactions.
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-004-6053-0