Role of exposure to radon and silicosis on the cell type of lung carcinoma in German uranium miners

• Published in: Cancer 2006-02, Vol.106 (4), p.881-889
• Main Authors: Taeger, Dirk, Fritsch, Arno, Wiethege, Thorsten, Johnen, Georg, Eisenmenger, Andreas, Wesch, Horst, Ko, Yon, Stier, Sebastian, Michael Muller, Klaus, Bruning, Thomas, Pesch, Beate
• Format: Article
• Language: English
• Subjects: Aged; Autopsy; Biological and medical sciences; Carcinoma, Non-Small-Cell Lung - etiology; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Small Cell - etiology; Carcinoma, Small Cell - pathology; Carcinoma, Squamous Cell - etiology; Carcinoma, Squamous Cell - pathology; Chemical and industrial products toxicology. Toxic occupational diseases; Dust; Germany; histology; Humans; Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.); Job Description; lung carcinoma; Lung Neoplasms - etiology; Lung Neoplasms - pathology; Male; Medical sciences; Middle Aged; Mining; Occupational Exposure; Odds Ratio; Quartz; radon; Radon - adverse effects; Retrospective Studies; silicosis; Silicosis - complications; Silicosis - etiology; Toxicology; Tumors; Uranium; uranium mining
• ISSN: 0008-543X; 1097-0142
• DOI: 10.1002/cncr.21677

BACKGROUND In East Germany, uranium mining was undertaken on a large scale from 1946 to 1990. Poor working conditions led to a high level of exposure to ionizing radiation and quartz dust. This analysis evaluates the histopathology of lung carcinoma in uranium miners in relation to radon exposure and silicosis. METHODS A database developed for autopsy cases ascertained in a pathological tissue repository of German uranium miners was used to estimate odds ratios for developing lung carcinoma by major cell type with regard to radon exposure and silicosis. Silicosis information was extracted from autopsy protocols. Working level months (WLM) were calculated with a job‐exposure matrix to assess lifetime radon exposure. Risk estimates were based on 3414 male miners who died from small cell lung carcinoma (SCLC, n = 1446), squamous cell carcinoma (SqCC, n = 1006), or adenocarcinoma (AC, n = 962) between 1957 and 1990. RESULTS SCLC and SqCC seem more likely to be associated with high radon exposure than AC. Mean cumulative radon exposure was 868 (SD 631) WLM in SCLC, 871 (SD 652) WLM in SqCC, and 743 (SD 598) WLM in AC. Silicosis prevalence was 26% in SCLC, 38% in SqCC, and 30% in AC. In silicotics, AC and SqCC had a relatively higher frequency at the expense of SCLC. SCLC occurred earlier than AC and SqCC. CONCLUSION High radon exposure was associated with a higher relative frequency of SCLC and SqCC than AC. Silicosis tended to increase the appearance of SqCC and AC. Cancer 2006. © 2006 American Cancer Society. In 3414 German uranium miners exposed to high levels of ionizing radiation and respirable quartz dust, small cell lung carcinoma (SCLC) and squamous cell carcinoma (SqCC) seem to be more likely associated with high radon exposure than adenocarcinoma (AC). In miners with silicosis, AC and SqCC had a relative higher frequency at the expense of SCLC.