Polymorphism of the adrenergic receptor alpha 2a -1291C>G genetic variation and clozapine-induced weight gain

Weight gain, leading to further morbidity and poor treatment compliance, is a common consequence of treatment with clozapine. The substantial interindividual and interracial differences in drug-induced weight gain suggest that genetic factors may be important. Several studies showed that alpha-2, ad...

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Bibliographic Details
Published in:Journal of Neural Transmission 2005-11, Vol.112 (11), p.1463-1468
Main Authors: Wang, Y-C, Bai, Y-M, Chen, J-Y, Lin, C-C, Lai, I-C, Liou, Y-J
Format: Article
Language:English
Subjects:
Adult
Antipsychotic Agents - adverse effects
Base Sequence - genetics
Clozapine - adverse effects
Cytosine - metabolism
Female
Genetic Predisposition to Disease - genetics
Genetic Variation - genetics
Genotype
Guanine - metabolism
Humans
Hypothalamo-Hypophyseal System - drug effects
Hypothalamo-Hypophyseal System - metabolism
Hypothalamo-Hypophyseal System - physiopathology
Male
Middle Aged
Obesity - chemically induced
Obesity - genetics
Obesity - physiopathology
Point Mutation - genetics
Polymorphism, Genetic - genetics
Receptors, Adrenergic, alpha-2 - drug effects
Receptors, Adrenergic, alpha-2 - genetics
Weight Gain - drug effects
Weight Gain - physiology
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Summary:Weight gain, leading to further morbidity and poor treatment compliance, is a common consequence of treatment with clozapine. The substantial interindividual and interracial differences in drug-induced weight gain suggest that genetic factors may be important. Several studies showed that alpha-2, adrenoceptor may related to feeding behavior with rat or lipolytic activity of human adipocyte tissue, they are related to body weight change. In the study, we try to test the possible relation of clozapine-induced weight gain and adrenergic receptor alpha 2a -1291C>G genetic polymorphism in a long term follow up (14.0 +/- 6.2 months). Our results show the genotype GG (8.45 +/- 7.2 Kg) with higher mean body weight gain than genotype CC (2.79 +/- 6.1 Kg) (p = 0.023). The finding identify a genetic factor associated with clozapine-induced weight gain in schizophrenic patients.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-005-0291-7