Three-dimensional alteration of cervical anterior spinal artery and anterior radicular artery in rat model of chronic spinal cord compression by micro-CT

•The 3d variation of cervical anterior spinal artery and anterior radicular artery can be shown by micro-CT after chronic spinal cord compression.•The most serious neurological damage occurred at the 28th day after chronic compression.•Neural functional recovery was accompanied by vascular alteratio...

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Bibliographic Details
Published in:Neuroscience letters 2015-10, Vol.606, p.106-112
Main Authors: Cheng, Xing, Long, HouQing, Chen, WenLi, Xu, JingHui, Huang, YangLiang, Li, FoBao
Format: Article
Language:English
Subjects:
3D micro-CT
Animals
Anterior radicular artery
Anterior spinal artery
Cervical Vertebrae - blood supply
Cervical Vertebrae - diagnostic imaging
Chronic spinal cord compression
Evoked Potentials, Somatosensory
Neurological function
Rats, Sprague-Dawley
Spinal Cord - blood supply
Spinal Cord - diagnostic imaging
Spinal Cord Compression - diagnostic imaging
Spinal Cord Compression - pathology
Spinal Cord Compression - physiopathology
Tomography, X-Ray Computed
Vertebral Artery - diagnostic imaging
Vertebral Artery - pathology
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Summary:•The 3d variation of cervical anterior spinal artery and anterior radicular artery can be shown by micro-CT after chronic spinal cord compression.•The most serious neurological damage occurred at the 28th day after chronic compression.•Neural functional recovery was accompanied by vascular alteration. And this alteration has implications for studying the pathophysiology of cervical myelopathy. To investigate the spatial and temporal changes of anterior spinal artery (ASA) and anterior radicular artery (ARA) of chronic compressive spinal cord injury on rat model by three-dimensional micro-CT. 48 rats were divided into two groups: sham control group (n=24) and compressive spinal cord injury group (n=24). A C6 semi-laminectomy was performed in the sham control group, while a water-absorbable polyurethane polymer was implanted into C6 epidural space in the compression group. The Basso Beattie Bresnahan (BBB) score and somatosensory evoked potentials (SEP) were used to evaluate neurological function. Micro-CT scanning was used to investigate the change of ASA and ARA after perfusion at the 1th (n=6), 28th (n=6), 42th (n=6) and 70th (n=6) day of post operation. The diameter, angle-off and vascular index (VI) was measured by 3D micro-CT. In comparison with sham control, BBB score have a significant reduction at the 28th day (p
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2015.08.050