Identification of layers in optical coherence tomography of skin: comparative analysis of experimental and Monte Carlo simulated images

Background/purpose The goal of the study is comparative analysis of the layers in OCT images and the morphological structure of skin with thick and thin epidermis. Methods We analyzed the difference between skin with thin and thick epidermis in two ways. The first approach consisted in determination...

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Bibliographic Details
Published in:Skin research and technology 2015-11, Vol.21 (4), p.419-425
Main Authors: Shlivko, I. L., Kirillin, M. Yu, Donchenko, E. V., Ellinsky, D. O., Garanina, O. E., Neznakhina, M. S., Agrba, P. D., Kamensky, V. A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Child
Child, Preschool
Comparative analysis
Computer Simulation
Female
Humans
Image Interpretation, Computer-Assisted - methods
Light
Male
Middle Aged
Models, Biological
Models, Statistical
Monte Carlo Method
Monte Carlo simulation
Morphology
Nephelometry and Turbidimetry - methods
optical coherence tomography
Scattering, Radiation
Skin - anatomy & histology
skin layers
Skin Physiological Phenomena
thick skin
thin skin
Tomography, Optical Coherence - methods
Young Adult
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Summary:Background/purpose The goal of the study is comparative analysis of the layers in OCT images and the morphological structure of skin with thick and thin epidermis. Methods We analyzed the difference between skin with thin and thick epidermis in two ways. The first approach consisted in determination of the thicknesses of layers of skin with thin and thick epidermis of different localizations from experimental OCT images. The second approach was to develop numerical models fitting experimental OCT images based on Monte Carlo simulations revealing structure and optical parameters of layers of skin with thick and thin epidermis. Results The correspondence between the OCT images of skin with thin and thick epidermis and the morphological structure was confirmed. OCT images of healthy skin comprise three layers in case of skin with thin epidermis and four layers in skin with thick epidermis. The OCT image of the zone of the transition from skin with thick to skin with thin epidermis features five layers. Conclusion The revealed differences in the structure of horny and cellular layers of epidermis, as well as of papillary and reticular dermis in skin with thin and thick epidermis specify different optical properties of these layers in OCT images.
ISSN:0909-752X
1600-0846
DOI:10.1111/srt.12209