Loading…

Effective Treatment of Autoimmune Disease and Progressive Renal Disease by Mixed Bone-Marrow Transplantation That Establishes a Stable Mixed Chimerism in BXSB Recipient Mice

Male BXSB mice spontaneously develop autoimmune disease with features similar to systemic lupus erythematosus. To determine whether this autoimmune disease can be treated as well as prevented by bone-marrow transplantation (BMT) and, at the same time, whether the immunity functions of lethally irrad...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1999-03, Vol.96 (6), p.3012-3016
Main Authors: Wang, Bingyan, Yamamoto, Yoshihisa, El-Badri, Nagwa S., Good, Robert A.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c514t-cb4ce7efcdd1e37e729e502292f8f4e1c005001e718454e6bb8e6954d748ee883
cites cdi_FETCH-LOGICAL-c514t-cb4ce7efcdd1e37e729e502292f8f4e1c005001e718454e6bb8e6954d748ee883
container_end_page 3016
container_issue 6
container_start_page 3012
container_title Proceedings of the National Academy of Sciences - PNAS
container_volume 96
creator Wang, Bingyan
Yamamoto, Yoshihisa
El-Badri, Nagwa S.
Good, Robert A.
description Male BXSB mice spontaneously develop autoimmune disease with features similar to systemic lupus erythematosus. To determine whether this autoimmune disease can be treated as well as prevented by bone-marrow transplantation (BMT) and, at the same time, whether the immunity functions of lethally irradiated recipients can be reconstituted fully, male BXSB mice were engrafted with mixed T cell-depleted marrow (TCDM) both from fully allogeneic autoimmune-resistant BALB/c mice and from syngeneic autoimmune-prone BXSB mice, after the onset of autoimmune disease in the recipient mice. BMT with mixed TCDM from both resistant and susceptible strains of mice (mixed BMT) established stable mixed chimerism, prolonged the median life span, and arrested development of glomerulonephritis in BXSB mice. BMT with mixed TCDM also reduced the formation of anti-DNA antibodies that are observed typically in male mice of this strain. Furthermore, mixed BMT reconstituted the primary antibody production in BXSB recipients impressively. These findings indicate that transplantation of allogeneic autoimmune-resistant TCDM plus syngeneic autoimmune-prone TCDM into lethally irradiated BXSB mice can be used to treat autoimmune and renal disease in this strain of mice. In addition, this dual bone-marrow transplantation reconstitutes the immunity functions and avoids the immunodeficiencies that occur regularly in fully allogeneic chimeras after total body irradiation. This report describes an effective treatment of progressive renal disease and autoimmunity by establishing a stable mixed chimerism of TCDM transplantation from allogeneic autoimmune-resistant BALB/c mice plus syngeneic autoimmune-prone BXSB mice into BXSB mice.
doi_str_mv 10.1073/pnas.96.6.3012
format article
fullrecord <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_17215090</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>47480</jstor_id><sourcerecordid>47480</sourcerecordid><originalsourceid>FETCH-LOGICAL-c514t-cb4ce7efcdd1e37e729e502292f8f4e1c005001e718454e6bb8e6954d748ee883</originalsourceid><addsrcrecordid>eNqFks1v0zAYxiMEYmVw5YAEsjjslvI6H44t7bJ25UNaBWJF4mY5yZvVVRIX2xnbH7X_EUctVeEAJ8t6fs_7pSeKXlKYUijSd9teualgUzZNgSaPogkFQWOWCXgcTQCSIuZZkp1Ez5zbAIDIOTyNTihAUbCET6KHRdNg5fUtkpVF5TvsPTENuRi80V039EgutUPlkKi-Jl-subHo3Mh_xV61B7W8J0t9hzWZmR7jpbLW_AwlVe-2req98tr0ZLVWniycV2Wr3RodUeR6_ODeO1_rDq12HdE9mX2_noUmld7qcailrvB59KRRrcMX-_c0-vZ-sZp_jK8-f_g0v7iKq5xmPq7KrMICm6quKaYFFonAHJJEJA1vMqQVQA5AsaA8yzNkZcmRiTyri4wjcp6eRue7utuh7LCuQn-rWrm1ulP2Xhql5Z9Kr9fyxtxKmnPOgv1sb7fmx4DOy067CttwCDSDk0ywRFBO_wvSIqE5CAjg27_AjRlsuL-TCdC0SCHNAzTdQZU1zllsDgNTkGNa5JgWKZhkckxLMLw5XvMI38UjAK_3wGj8LR8XOPuXLpuhbT3e-QC-2oEb5409kFk4OKS_APsZ3uA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>201373035</pqid></control><display><type>article</type><title>Effective Treatment of Autoimmune Disease and Progressive Renal Disease by Mixed Bone-Marrow Transplantation That Establishes a Stable Mixed Chimerism in BXSB Recipient Mice</title><source>JSTOR Archival Journals and Primary Sources Collection</source><source>PubMed Central</source><creator>Wang, Bingyan ; Yamamoto, Yoshihisa ; El-Badri, Nagwa S. ; Good, Robert A.</creator><creatorcontrib>Wang, Bingyan ; Yamamoto, Yoshihisa ; El-Badri, Nagwa S. ; Good, Robert A.</creatorcontrib><description>Male BXSB mice spontaneously develop autoimmune disease with features similar to systemic lupus erythematosus. To determine whether this autoimmune disease can be treated as well as prevented by bone-marrow transplantation (BMT) and, at the same time, whether the immunity functions of lethally irradiated recipients can be reconstituted fully, male BXSB mice were engrafted with mixed T cell-depleted marrow (TCDM) both from fully allogeneic autoimmune-resistant BALB/c mice and from syngeneic autoimmune-prone BXSB mice, after the onset of autoimmune disease in the recipient mice. BMT with mixed TCDM from both resistant and susceptible strains of mice (mixed BMT) established stable mixed chimerism, prolonged the median life span, and arrested development of glomerulonephritis in BXSB mice. BMT with mixed TCDM also reduced the formation of anti-DNA antibodies that are observed typically in male mice of this strain. Furthermore, mixed BMT reconstituted the primary antibody production in BXSB recipients impressively. These findings indicate that transplantation of allogeneic autoimmune-resistant TCDM plus syngeneic autoimmune-prone TCDM into lethally irradiated BXSB mice can be used to treat autoimmune and renal disease in this strain of mice. In addition, this dual bone-marrow transplantation reconstitutes the immunity functions and avoids the immunodeficiencies that occur regularly in fully allogeneic chimeras after total body irradiation. This report describes an effective treatment of progressive renal disease and autoimmunity by establishing a stable mixed chimerism of TCDM transplantation from allogeneic autoimmune-resistant BALB/c mice plus syngeneic autoimmune-prone BXSB mice into BXSB mice.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.96.6.3012</identifier><identifier>PMID: 10077628</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Animals ; Antibodies ; Antibody formation ; Autoimmune diseases ; Autoimmune Diseases - immunology ; Autoimmune Diseases - therapy ; Biological Sciences ; Bone marrow ; Bone Marrow Transplantation ; Chimeras ; Chimerism ; Disease ; Glomerulonephritis ; Immune system ; Kidney Diseases - immunology ; Kidney Diseases - therapy ; Lesions ; Lupus Erythematosus, Systemic - immunology ; Lupus Erythematosus, Systemic - therapy ; Lymphocyte Depletion ; Male ; Mice ; Plant diseases ; Rodents ; T-Lymphocytes - immunology ; Transplantation ; Transplantation Chimera ; Transplantation Immunology ; Transplantation, Homologous ; Transplantation, Isogeneic ; Transplants &amp; implants</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1999-03, Vol.96 (6), p.3012-3016</ispartof><rights>Copyright 1993-1999 The National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Mar 16, 1999</rights><rights>Copyright © 1999, The National Academy of Sciences 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-cb4ce7efcdd1e37e729e502292f8f4e1c005001e718454e6bb8e6954d748ee883</citedby><cites>FETCH-LOGICAL-c514t-cb4ce7efcdd1e37e729e502292f8f4e1c005001e718454e6bb8e6954d748ee883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/96/6.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/47480$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/47480$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793,58238,58471</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10077628$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Bingyan</creatorcontrib><creatorcontrib>Yamamoto, Yoshihisa</creatorcontrib><creatorcontrib>El-Badri, Nagwa S.</creatorcontrib><creatorcontrib>Good, Robert A.</creatorcontrib><title>Effective Treatment of Autoimmune Disease and Progressive Renal Disease by Mixed Bone-Marrow Transplantation That Establishes a Stable Mixed Chimerism in BXSB Recipient Mice</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Male BXSB mice spontaneously develop autoimmune disease with features similar to systemic lupus erythematosus. To determine whether this autoimmune disease can be treated as well as prevented by bone-marrow transplantation (BMT) and, at the same time, whether the immunity functions of lethally irradiated recipients can be reconstituted fully, male BXSB mice were engrafted with mixed T cell-depleted marrow (TCDM) both from fully allogeneic autoimmune-resistant BALB/c mice and from syngeneic autoimmune-prone BXSB mice, after the onset of autoimmune disease in the recipient mice. BMT with mixed TCDM from both resistant and susceptible strains of mice (mixed BMT) established stable mixed chimerism, prolonged the median life span, and arrested development of glomerulonephritis in BXSB mice. BMT with mixed TCDM also reduced the formation of anti-DNA antibodies that are observed typically in male mice of this strain. Furthermore, mixed BMT reconstituted the primary antibody production in BXSB recipients impressively. These findings indicate that transplantation of allogeneic autoimmune-resistant TCDM plus syngeneic autoimmune-prone TCDM into lethally irradiated BXSB mice can be used to treat autoimmune and renal disease in this strain of mice. In addition, this dual bone-marrow transplantation reconstitutes the immunity functions and avoids the immunodeficiencies that occur regularly in fully allogeneic chimeras after total body irradiation. This report describes an effective treatment of progressive renal disease and autoimmunity by establishing a stable mixed chimerism of TCDM transplantation from allogeneic autoimmune-resistant BALB/c mice plus syngeneic autoimmune-prone BXSB mice into BXSB mice.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Antibody formation</subject><subject>Autoimmune diseases</subject><subject>Autoimmune Diseases - immunology</subject><subject>Autoimmune Diseases - therapy</subject><subject>Biological Sciences</subject><subject>Bone marrow</subject><subject>Bone Marrow Transplantation</subject><subject>Chimeras</subject><subject>Chimerism</subject><subject>Disease</subject><subject>Glomerulonephritis</subject><subject>Immune system</subject><subject>Kidney Diseases - immunology</subject><subject>Kidney Diseases - therapy</subject><subject>Lesions</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Lupus Erythematosus, Systemic - therapy</subject><subject>Lymphocyte Depletion</subject><subject>Male</subject><subject>Mice</subject><subject>Plant diseases</subject><subject>Rodents</subject><subject>T-Lymphocytes - immunology</subject><subject>Transplantation</subject><subject>Transplantation Chimera</subject><subject>Transplantation Immunology</subject><subject>Transplantation, Homologous</subject><subject>Transplantation, Isogeneic</subject><subject>Transplants &amp; implants</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqFks1v0zAYxiMEYmVw5YAEsjjslvI6H44t7bJ25UNaBWJF4mY5yZvVVRIX2xnbH7X_EUctVeEAJ8t6fs_7pSeKXlKYUijSd9teualgUzZNgSaPogkFQWOWCXgcTQCSIuZZkp1Ez5zbAIDIOTyNTihAUbCET6KHRdNg5fUtkpVF5TvsPTENuRi80V039EgutUPlkKi-Jl-subHo3Mh_xV61B7W8J0t9hzWZmR7jpbLW_AwlVe-2req98tr0ZLVWniycV2Wr3RodUeR6_ODeO1_rDq12HdE9mX2_noUmld7qcailrvB59KRRrcMX-_c0-vZ-sZp_jK8-f_g0v7iKq5xmPq7KrMICm6quKaYFFonAHJJEJA1vMqQVQA5AsaA8yzNkZcmRiTyri4wjcp6eRue7utuh7LCuQn-rWrm1ulP2Xhql5Z9Kr9fyxtxKmnPOgv1sb7fmx4DOy067CttwCDSDk0ywRFBO_wvSIqE5CAjg27_AjRlsuL-TCdC0SCHNAzTdQZU1zllsDgNTkGNa5JgWKZhkckxLMLw5XvMI38UjAK_3wGj8LR8XOPuXLpuhbT3e-QC-2oEb5409kFk4OKS_APsZ3uA</recordid><startdate>19990316</startdate><enddate>19990316</enddate><creator>Wang, Bingyan</creator><creator>Yamamoto, Yoshihisa</creator><creator>El-Badri, Nagwa S.</creator><creator>Good, Robert A.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><general>The National Academy of Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19990316</creationdate><title>Effective Treatment of Autoimmune Disease and Progressive Renal Disease by Mixed Bone-Marrow Transplantation That Establishes a Stable Mixed Chimerism in BXSB Recipient Mice</title><author>Wang, Bingyan ; Yamamoto, Yoshihisa ; El-Badri, Nagwa S. ; Good, Robert A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-cb4ce7efcdd1e37e729e502292f8f4e1c005001e718454e6bb8e6954d748ee883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>Antibody formation</topic><topic>Autoimmune diseases</topic><topic>Autoimmune Diseases - immunology</topic><topic>Autoimmune Diseases - therapy</topic><topic>Biological Sciences</topic><topic>Bone marrow</topic><topic>Bone Marrow Transplantation</topic><topic>Chimeras</topic><topic>Chimerism</topic><topic>Disease</topic><topic>Glomerulonephritis</topic><topic>Immune system</topic><topic>Kidney Diseases - immunology</topic><topic>Kidney Diseases - therapy</topic><topic>Lesions</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>Lupus Erythematosus, Systemic - therapy</topic><topic>Lymphocyte Depletion</topic><topic>Male</topic><topic>Mice</topic><topic>Plant diseases</topic><topic>Rodents</topic><topic>T-Lymphocytes - immunology</topic><topic>Transplantation</topic><topic>Transplantation Chimera</topic><topic>Transplantation Immunology</topic><topic>Transplantation, Homologous</topic><topic>Transplantation, Isogeneic</topic><topic>Transplants &amp; implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Bingyan</creatorcontrib><creatorcontrib>Yamamoto, Yoshihisa</creatorcontrib><creatorcontrib>El-Badri, Nagwa S.</creatorcontrib><creatorcontrib>Good, Robert A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Bingyan</au><au>Yamamoto, Yoshihisa</au><au>El-Badri, Nagwa S.</au><au>Good, Robert A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effective Treatment of Autoimmune Disease and Progressive Renal Disease by Mixed Bone-Marrow Transplantation That Establishes a Stable Mixed Chimerism in BXSB Recipient Mice</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1999-03-16</date><risdate>1999</risdate><volume>96</volume><issue>6</issue><spage>3012</spage><epage>3016</epage><pages>3012-3016</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Male BXSB mice spontaneously develop autoimmune disease with features similar to systemic lupus erythematosus. To determine whether this autoimmune disease can be treated as well as prevented by bone-marrow transplantation (BMT) and, at the same time, whether the immunity functions of lethally irradiated recipients can be reconstituted fully, male BXSB mice were engrafted with mixed T cell-depleted marrow (TCDM) both from fully allogeneic autoimmune-resistant BALB/c mice and from syngeneic autoimmune-prone BXSB mice, after the onset of autoimmune disease in the recipient mice. BMT with mixed TCDM from both resistant and susceptible strains of mice (mixed BMT) established stable mixed chimerism, prolonged the median life span, and arrested development of glomerulonephritis in BXSB mice. BMT with mixed TCDM also reduced the formation of anti-DNA antibodies that are observed typically in male mice of this strain. Furthermore, mixed BMT reconstituted the primary antibody production in BXSB recipients impressively. These findings indicate that transplantation of allogeneic autoimmune-resistant TCDM plus syngeneic autoimmune-prone TCDM into lethally irradiated BXSB mice can be used to treat autoimmune and renal disease in this strain of mice. In addition, this dual bone-marrow transplantation reconstitutes the immunity functions and avoids the immunodeficiencies that occur regularly in fully allogeneic chimeras after total body irradiation. This report describes an effective treatment of progressive renal disease and autoimmunity by establishing a stable mixed chimerism of TCDM transplantation from allogeneic autoimmune-resistant BALB/c mice plus syngeneic autoimmune-prone BXSB mice into BXSB mice.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>10077628</pmid><doi>10.1073/pnas.96.6.3012</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0027-8424
ispartof Proceedings of the National Academy of Sciences - PNAS, 1999-03, Vol.96 (6), p.3012-3016
issn 0027-8424
1091-6490
language eng
recordid cdi_proquest_miscellaneous_17215090
source JSTOR Archival Journals and Primary Sources Collection; PubMed Central
subjects Animals
Antibodies
Antibody formation
Autoimmune diseases
Autoimmune Diseases - immunology
Autoimmune Diseases - therapy
Biological Sciences
Bone marrow
Bone Marrow Transplantation
Chimeras
Chimerism
Disease
Glomerulonephritis
Immune system
Kidney Diseases - immunology
Kidney Diseases - therapy
Lesions
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - therapy
Lymphocyte Depletion
Male
Mice
Plant diseases
Rodents
T-Lymphocytes - immunology
Transplantation
Transplantation Chimera
Transplantation Immunology
Transplantation, Homologous
Transplantation, Isogeneic
Transplants & implants
title Effective Treatment of Autoimmune Disease and Progressive Renal Disease by Mixed Bone-Marrow Transplantation That Establishes a Stable Mixed Chimerism in BXSB Recipient Mice
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T21%3A48%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effective%20Treatment%20of%20Autoimmune%20Disease%20and%20Progressive%20Renal%20Disease%20by%20Mixed%20Bone-Marrow%20Transplantation%20That%20Establishes%20a%20Stable%20Mixed%20Chimerism%20in%20BXSB%20Recipient%20Mice&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Wang,%20Bingyan&rft.date=1999-03-16&rft.volume=96&rft.issue=6&rft.spage=3012&rft.epage=3016&rft.pages=3012-3016&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/10.1073/pnas.96.6.3012&rft_dat=%3Cjstor_proqu%3E47480%3C/jstor_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c514t-cb4ce7efcdd1e37e729e502292f8f4e1c005001e718454e6bb8e6954d748ee883%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=201373035&rft_id=info:pmid/10077628&rft_jstor_id=47480&rfr_iscdi=true