EUS and EUS–FNA diagnosis of suspected pancreatic cystic neoplasms: Is the sum of the parts greater than the CEA?

Abstract Background Carcinoembryonic antigen (CEA) is suggested as the single most useful EUS/EUS–FNA derived test for the diagnosis of mucinous pancreatic cysts. Study aims To investigate the yield and diagnostic performance of EUS/EUS–FNA on an intention to diagnose basis and to determine the util...

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Bibliographic Details
Published in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2015-09, Vol.15 (5), p.531-537
Main Authors: Oppong, K.W, Dawwas, M.F, Charnley, R.M, Wadehra, V, Elamin, K, White, S, Nayar, M
Format: Article
Language:English
Subjects:
Accuracy
Adult
Aged
Aged, 80 and over
Amylases - metabolism
Carcinoembryonic Antigen - metabolism
Cellular biology
Cysts
Cytology
Endocrinology & Metabolism
Endoscopic ultrasound
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Endosonography
Female
Fine needle aspiration
Gastroenterology and Hepatology
Humans
Male
Middle Aged
Neoplasms, Cystic, Mucinous, and Serous - diagnosis
Neoplasms, Cystic, Mucinous, and Serous - diagnostic imaging
Neoplasms, Cystic, Mucinous, and Serous - metabolism
Neoplasms, Cystic, Mucinous, and Serous - pathology
Pancreas
Pancreas - diagnostic imaging
Pancreas - metabolism
Pancreas - pathology
Pancreas cysts
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - diagnostic imaging
Pancreatic Neoplasms - metabolism
Pancreatic Neoplasms - pathology
Retrospective Studies
Sensitivity and Specificity
Specificity
Tumors
Tumour markers
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Summary:Abstract Background Carcinoembryonic antigen (CEA) is suggested as the single most useful EUS/EUS–FNA derived test for the diagnosis of mucinous pancreatic cysts. Study aims To investigate the yield and diagnostic performance of EUS/EUS–FNA on an intention to diagnose basis and to determine the utility of the recommended CEA and amylase cut-off values. Patients and methods A retrospective study of a prospectively maintained database of 433 procedures performed in a 10 year period. Diagnostic performance of EUS–FNA was determined in 133 procedures with a definite diagnosis. Results CEA value was determined in significantly fewer procedures (58.6%) than EUS diagnosis was stated (83.4%; p 
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2015.08.001