Papillary-like main pancreatic duct invaginated pancreaticojejunostomy versus duct-to-mucosa pancreaticojejunostomy after pancreaticoduodenectomy: A prospective randomized trial

• Published in: Surgery 2015-11, Vol.158 (5), p.1211-1218
• Main Authors: Xu, Jin, MD, Zhang, Bo, MD, Shi, Si, MD, Qin, Yi, PhD, Ji, Shunrong, MD, Xu, Wenyan, MD, Liu, Jiang, MD, Liu, Liang, MD, Liu, Chen, MD, Long, Jiang, MD, Ni, Quanxing, MD, Yu, Xianjun, MD
• Format: Article
• Language: English
• Subjects: Aged; Body Mass Index; Female; Humans; Male; Middle Aged; Operative Time; Pancreatic Fistula - etiology; Pancreatic Fistula - prevention & control; Pancreatic Neoplasms - complications; Pancreatic Neoplasms - pathology; Pancreatic Neoplasms - surgery; Pancreaticoduodenectomy - adverse effects; Pancreaticojejunostomy - adverse effects; Pancreaticojejunostomy - methods; Prospective Studies; Surgery; Treatment Outcome
• ISSN: 0039-6060; 1532-7361
• DOI: 10.1016/j.surg.2015.04.020

Background Development of a postoperative pancreatic fistula (POPF) is the single most significant complication of pancreatic anastomosis, which is a key procedure in pancreaticoduodenectomy. We previously reported a new papillary-like pancreaticojejunostomy, and a retrospective study showed a benefit in reducing the incidence of grade B/C POPF compared with duct-to-mucosa pancreaticojejunostomy. The aim of this study was to reassess whether the new pancreaticojejunostomy would decrease the POPF rate. Methods A prospective, randomized, controlled trial (NCT01731821 registered at http://ClinicalTrials.gov ) involving 308 patients who underwent pancreaticoduodenectomy was conducted. Results The overall POPF rate was significantly lower in the papillary-like group compared with the duct-to-mucosa group (14/155 [9.0%] vs 31/153 [20.3%]; P  = .005), and the grade B/C POPF rate of the papillary-like group was significantly decreased compared with the duct-to-mucosa group. Multivariable analyses identified higher body mass index (odds ratio [OR], 3.520; P  = .000), longer operative time (OR, 2.587; P  = .041), soft texture and nondilated main pancreatic duct (OR, 0.365; P  = .014), and the duct-to-mucosa pancreaticojejunostomy (OR, 0.405; P  = .013) as significant risk factors for POPF. Further stratified analyses showed that, for patients with soft texture and nondilated main pancreatic duct, the POPF rate in the papillary-like group (9.6%) was significantly lower than that in the duct-to-mucosa group (27.3%). However, for patients with hard texture or dilated main pancreatic duct, there was no difference between the 2 groups (7.8% vs 8.6%; P  > 0.999). Conclusion The new papillary-like pancreaticojejunostomy may provide a better option for patients with soft texture and nondilated main pancreatic duct.