Association between the XRCC1 Arg399Gln polymorphism and risk of cervical carcinoma: a meta-analysis

• Published in: Genetics and molecular research 2015-08, Vol.14 (3), p.9821-9828
• Main Authors: Liu, D Y, Liang, H C, Xiao, X M
• Format: Article
• Language: English
• Subjects: Alleles; Amino Acid Substitution; Case-Control Studies; DNA-Binding Proteins - genetics; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Odds Ratio; Polymorphism, Single Nucleotide; Publication Bias; Uterine Cervical Neoplasms - genetics; X-ray Repair Cross Complementing Protein 1
• ISSN: 1676-5680; 1676-5680
• DOI: 10.4238/2015.August.19.15

Numerous studies have evaluated the association between Arg399Gln polymorphism of DNA repair gene XRCC1 and cervical carcinoma risk. However, the specific association is still controversial. To assess the relationship between XRCC1 Arg399Gln polymorphism and cervical carcinoma, we conducted a comprehensive meta-analysis of 10 case-control studies with 2051 cervical carcinoma cases and 2919 controls. Meta-analysis results based on all the studies showed a significant association between XRCC1 Arg399Gln polymorphism and cervical carcinoma risk (GlnGln vs ArgArg: OR = 1.29, 95%CI = 0.90-1.85; GlnGln vs ArgGln: OR = 1.15, 95%CI = 0.93-1.43; the dominant model: OR = 0.80, 95%CI = 0.66-0.99; the recessive model: OR = 1.18, 95%CI = 0.93-1.49). In the subgroup analysis by ethnicity, the results also showed significant association between XRCC1 Arg399Gln polymorphism and susceptibility to cervical carcinoma in both Caucasian and Asian populations. The Arg399Gln polymorphism in the XRCC1 gene may be related to the increased risk of cervical carcinoma. Conclusive evidence on the effects of the variants in cervical carcinoma should be addressed in further studies.