Phospholipase A2 receptor and sarcoidosis-associated membranous nephropathy

Of the glomerulonephritis associated with sarcoidosis, membranous nephropathy (MN) is the most prevalent. Coincidence or a causal relationship between these two diseases is unclear. Here, we present for the first time a high prevalence of PLA2R-related MN among patients with MN associated with activ...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2015-06, Vol.30 (6), p.1047-1050
Main Authors: Stehlé, Thomas, Audard, Vincent, Ronco, Pierre, Debiec, Hanna
Format: Article
Language:English
Subjects:
Adult
Antibodies, Anti-Idiotypic - blood
Female
France - epidemiology
Glomerulonephritis, Membranous - blood
Glomerulonephritis, Membranous - diagnosis
Glomerulonephritis, Membranous - epidemiology
Humans
Male
Middle Aged
Prevalence
Prognosis
Receptors, Phospholipase A2 - blood
Receptors, Phospholipase A2 - immunology
Retrospective Studies
Sarcoidosis - physiopathology
Young Adult
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Summary:Of the glomerulonephritis associated with sarcoidosis, membranous nephropathy (MN) is the most prevalent. Coincidence or a causal relationship between these two diseases is unclear. Here, we present for the first time a high prevalence of PLA2R-related MN among patients with MN associated with active sarcoidosis. Our results suggest some causal link between sarcoidosis and PLA2R-related MN. Detection of anti-PLA2R antibodies in serum or PLA2R antigen in biopsy should not be taken as evidence against a secondary cause, particularly sarcoidosis. This important observation can affect treatment decision in these patients.
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfv080