Prediction and prevention of early‐onset pre‐eclampsia: impact of aspirin after first‐trimester screening

• Published in: Ultrasound in obstetrics & gynecology 2015-10, Vol.46 (4), p.419-423
• Main Authors: Park, F., Russo, K., Williams, P., Pelosi, M., Puddephatt, R., Walter, M., Leung, C., Saaid, R., Rawashdeh, H., Ogle, R., Hyett, J.
• Format: Article
• Language: English
• Subjects: Adult; aspirin; Aspirin - administration & dosage; Australia - epidemiology; Cohort Studies; Female; first‐trimester prediction; Gestational Age; Humans; Infant, Newborn; mean arterial pressure; PAPP‐A; Platelet Aggregation Inhibitors - administration & dosage; Pre-Eclampsia - diagnosis; Pre-Eclampsia - diagnostic imaging; Pre-Eclampsia - epidemiology; Pre-Eclampsia - prevention & control; Predictive Value of Tests; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, First; pre‐eclampsia; Retrospective Studies; Risk Factors; Ultrasonography, Doppler, Pulsed - methods; uterine artery Doppler
• ISSN: 0960-7692; 1469-0705
• DOI: 10.1002/uog.14819

Objective To examine the effect of a combination of screening and treatment with low‐dose aspirin on the prevalence of early‐onset pre‐eclampsia (PE). Methods This was a retrospective analysis of two consecutive cohorts of women screened for early PE. The first cohort was observed to determine whether algorithms developed to screen for PE at 11 to 13 + 6 weeks' gestation could be applied to our population. High‐risk women in the second cohort were advised on their risk and offered aspirin (150 mg at night), with treatment starting immediately after screening. The prevalence of early PE and the proportion of women with PE delivering at 34–37 weeks' gestation were compared between the cohorts. Results In the observational and interventional cohorts, 3066 and 2717 women, respectively, were screened. There were 12 (0.4%) cases of early PE in the observational cohort and one (0.04%) in the interventional cohort (P