Serum hepcidin concentrations correlate with serum iron level and outcome in patients with intracerebral hemorrhage

• Published in: Neurological sciences 2015-10, Vol.36 (10), p.1843-1849
• Main Authors: Xiong, Xiao-Yi, Chen, Jing, Zhu, Wen-Yao, Zhao, Ting, Zhong, Qi, Zhou, Kai, Meng, Zhao-You, Wang, Yan-Chun, Wang, Peng-Fei, Fang, Huang, Yang, Qing-Wu
• Format: Article
• Language: English
• Subjects: Biomarkers - blood; Blood Chemical Analysis; Cerebral Hemorrhage - blood; Cerebral Hemorrhage - diagnosis; Enzyme-Linked Immunosorbent Assay; Female; Hepcidins - blood; Humans; Interleukin-6 - blood; Iron - blood; Linear Models; Male; Medicine; Medicine & Public Health; Middle Aged; Neurology; Neuroradiology; Neurosciences; Neurosurgery; Original Article; Prognosis; Psychiatry; Severity of Illness Index; Tumor Necrosis Factor-alpha - blood
• ISSN: 1590-1874; 1590-3478
• DOI: 10.1007/s10072-015-2266-2

Iron plays a detrimental role in the intracerebral hemorrhage (ICH)-induced brain damage, while hepcidin is the most important iron-regulated hormone. Here, we investigate the association between serum hepcidin and serum iron, outcome in patients with ICH. Serum samples of 81 cases with ICH were obtained on consecutive days to detect the levels of hepcidin, iron, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). The National Institutes of Health Stroke Scale score (NIHSS) was measured at admission and on days 7 and 30, and the modified Rankin Scale (mRS) score was evaluated at 3 months after ICH. Additionally, the correlations of serum hepcidin with serum iron and the mRS score were analyzed by a generalized linear model. Higher serum hepcidin levels were detected in patients with poor outcomes ( P