Podocalyxin-like protein 1 functions as an immunomodulatory molecule in breast cancer cells

Highlights • PCLP1 increases tumor cell resistance to NK cell-mediated lysis. • PCLP1 expressed on breast cancer cells decreases the levels of NK cell activating receptors. • PCLP1 localizes to the immunological synapse and is acquired by NK cells from tumor cells. • PCLP1 expressed on breast cancer...

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Bibliographic Details
Published in:Cancer letters 2015-11, Vol.368 (1), p.26-35
Main Authors: Amo, Laura, Tamayo-Orbegozo, Estíbaliz, Maruri, Natalia, Buqué, Aitziber, Solaun, Miren, Riñón, Marta, Arrieta, Arantza, Larrucea, Susana
Format: Article
Language:English
Subjects:
Antigens
Apoptosis
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - immunology
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
CD16 antigen
CD226 antigen
CD34 antigen
Cell Communication
Cell Proliferation
Cell surface
Coculture Techniques
Cytolysis
Cytotoxicity
Cytotoxicity, Immunologic
Dendritic cells
Dendritic Cells - immunology
Dendritic Cells - metabolism
Female
Hematology, Oncology and Palliative Medicine
Humans
Immune evasion
Immune response
Immunomodulation
Immunomodulators
Killer Cells, Natural - immunology
Killer Cells, Natural - metabolism
Kinases
Lymphocyte Activation
Lymphocytes
Lymphocytes T
MCF-7 Cells
Metastases
Monoclonal antibodies
Natural killer cells
NK cells
NKG2 antigen
Plasma membranes
Podocalyxin
Receptors, Immunologic - immunology
Receptors, Immunologic - metabolism
Sialoglycoproteins - genetics
Sialoglycoproteins - immunology
Sialoglycoproteins - metabolism
Signal Transduction
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
Time Factors
Transfection
Tumor cells
Tumor Escape
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Summary:Highlights • PCLP1 increases tumor cell resistance to NK cell-mediated lysis. • PCLP1 expressed on breast cancer cells decreases the levels of NK cell activating receptors. • PCLP1 localizes to the immunological synapse and is acquired by NK cells from tumor cells. • PCLP1 expressed on breast cancer cells impairs T cell proliferation.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2015.06.029