Podocalyxin-like protein 1 functions as an immunomodulatory molecule in breast cancer cells

Highlights • PCLP1 increases tumor cell resistance to NK cell-mediated lysis. • PCLP1 expressed on breast cancer cells decreases the levels of NK cell activating receptors. • PCLP1 localizes to the immunological synapse and is acquired by NK cells from tumor cells. • PCLP1 expressed on breast cancer...

Full description

Saved in:
Bibliographic Details
Published in:Cancer letters 2015-11, Vol.368 (1), p.26-35
Main Authors: Amo, Laura, Tamayo-Orbegozo, Estíbaliz, Maruri, Natalia, Buqué, Aitziber, Solaun, Miren, Riñón, Marta, Arrieta, Arantza, Larrucea, Susana
Format: Article
Language:English
Subjects:
Antigens
Apoptosis
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - immunology
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
CD16 antigen
CD226 antigen
CD34 antigen
Cell Communication
Cell Proliferation
Cell surface
Coculture Techniques
Cytolysis
Cytotoxicity
Cytotoxicity, Immunologic
Dendritic cells
Dendritic Cells - immunology
Dendritic Cells - metabolism
Female
Hematology, Oncology and Palliative Medicine
Humans
Immune evasion
Immune response
Immunomodulation
Immunomodulators
Killer Cells, Natural - immunology
Killer Cells, Natural - metabolism
Kinases
Lymphocyte Activation
Lymphocytes
Lymphocytes T
MCF-7 Cells
Metastases
Monoclonal antibodies
Natural killer cells
NK cells
NKG2 antigen
Plasma membranes
Podocalyxin
Receptors, Immunologic - immunology
Receptors, Immunologic - metabolism
Sialoglycoproteins - genetics
Sialoglycoproteins - immunology
Sialoglycoproteins - metabolism
Signal Transduction
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
Time Factors
Transfection
Tumor cells
Tumor Escape
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c544t-6a9b85ae2b338569eba94d48d56cc1d091b37b9baba8546dd0a45cd10fba597f3
cites cdi_FETCH-LOGICAL-c544t-6a9b85ae2b338569eba94d48d56cc1d091b37b9baba8546dd0a45cd10fba597f3
container_end_page 35
container_issue 1
container_start_page 26
container_title Cancer letters
container_volume 368
creator Amo, Laura
Tamayo-Orbegozo, Estíbaliz
Maruri, Natalia
Buqué, Aitziber
Solaun, Miren
Riñón, Marta
Arrieta, Arantza
Larrucea, Susana
description Highlights • PCLP1 increases tumor cell resistance to NK cell-mediated lysis. • PCLP1 expressed on breast cancer cells decreases the levels of NK cell activating receptors. • PCLP1 localizes to the immunological synapse and is acquired by NK cells from tumor cells. • PCLP1 expressed on breast cancer cells impairs T cell proliferation.
doi_str_mv 10.1016/j.canlet.2015.06.029
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1722176428</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0304383515005182</els_id><sourcerecordid>1722176428</sourcerecordid><originalsourceid>FETCH-LOGICAL-c544t-6a9b85ae2b338569eba94d48d56cc1d091b37b9baba8546dd0a45cd10fba597f3</originalsourceid><addsrcrecordid>eNqNkkuLFTEQhYMoznX0H4g0uHHTbd5JbwQZ1BEGFNSVi5BHXciddGdMusX7701zRwdmoxCozVcnp-oUQs8JHggm8vVh8HZOsAwUEzFgOWA6PkA7ohXt1ajxQ7TDDPOeaSbO0JNaDxhjwZV4jM6opEoqwnfo--ccsrfp-CvOfYrX0N2UvECcO9Lt19kvMc-1s-3NXZymdc5TDmuySy7HbsoJ_Jqga7grYOvSNU8eSuchpfoUPdrbVOHZbT1H396_-3px2V99-vDx4u1V7wXnSy_t6LSwQB1jWsgRnB154DoI6T0JeCSOKTc666wWXIaALRc-ELx3Voxqz87Rq5Nus_5jhbqYKdbNgZ0hr9UQRSlRklP9HyjWepRasIa-vIce8lrmNshGSaFGJkWj-InyJddaYG9uSpxsORqCzZaTOZhTTmbLyWBpWk6t7cWt-OomCH-b_gTTgDcnANrifkYopvoIbbchFvCLCTn-64f7Aj7FObaor-EI9W4WU6nB5st2K9upENGuhGjKfgP1v7qm</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1706579365</pqid></control><display><type>article</type><title>Podocalyxin-like protein 1 functions as an immunomodulatory molecule in breast cancer cells</title><source>ScienceDirect Journals</source><creator>Amo, Laura ; Tamayo-Orbegozo, Estíbaliz ; Maruri, Natalia ; Buqué, Aitziber ; Solaun, Miren ; Riñón, Marta ; Arrieta, Arantza ; Larrucea, Susana</creator><creatorcontrib>Amo, Laura ; Tamayo-Orbegozo, Estíbaliz ; Maruri, Natalia ; Buqué, Aitziber ; Solaun, Miren ; Riñón, Marta ; Arrieta, Arantza ; Larrucea, Susana</creatorcontrib><description>Highlights • PCLP1 increases tumor cell resistance to NK cell-mediated lysis. • PCLP1 expressed on breast cancer cells decreases the levels of NK cell activating receptors. • PCLP1 localizes to the immunological synapse and is acquired by NK cells from tumor cells. • PCLP1 expressed on breast cancer cells impairs T cell proliferation.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2015.06.029</identifier><identifier>PMID: 26276714</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Antigens ; Apoptosis ; Breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - immunology ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; CD16 antigen ; CD226 antigen ; CD34 antigen ; Cell Communication ; Cell Proliferation ; Cell surface ; Coculture Techniques ; Cytolysis ; Cytotoxicity ; Cytotoxicity, Immunologic ; Dendritic cells ; Dendritic Cells - immunology ; Dendritic Cells - metabolism ; Female ; Hematology, Oncology and Palliative Medicine ; Humans ; Immune evasion ; Immune response ; Immunomodulation ; Immunomodulators ; Killer Cells, Natural - immunology ; Killer Cells, Natural - metabolism ; Kinases ; Lymphocyte Activation ; Lymphocytes ; Lymphocytes T ; MCF-7 Cells ; Metastases ; Monoclonal antibodies ; Natural killer cells ; NK cells ; NKG2 antigen ; Plasma membranes ; Podocalyxin ; Receptors, Immunologic - immunology ; Receptors, Immunologic - metabolism ; Sialoglycoproteins - genetics ; Sialoglycoproteins - immunology ; Sialoglycoproteins - metabolism ; Signal Transduction ; T-Lymphocytes - immunology ; T-Lymphocytes - metabolism ; Time Factors ; Transfection ; Tumor cells ; Tumor Escape</subject><ispartof>Cancer letters, 2015-11, Vol.368 (1), p.26-35</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2015 Elsevier Ireland Ltd</rights><rights>Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Nov 1, 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c544t-6a9b85ae2b338569eba94d48d56cc1d091b37b9baba8546dd0a45cd10fba597f3</citedby><cites>FETCH-LOGICAL-c544t-6a9b85ae2b338569eba94d48d56cc1d091b37b9baba8546dd0a45cd10fba597f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26276714$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amo, Laura</creatorcontrib><creatorcontrib>Tamayo-Orbegozo, Estíbaliz</creatorcontrib><creatorcontrib>Maruri, Natalia</creatorcontrib><creatorcontrib>Buqué, Aitziber</creatorcontrib><creatorcontrib>Solaun, Miren</creatorcontrib><creatorcontrib>Riñón, Marta</creatorcontrib><creatorcontrib>Arrieta, Arantza</creatorcontrib><creatorcontrib>Larrucea, Susana</creatorcontrib><title>Podocalyxin-like protein 1 functions as an immunomodulatory molecule in breast cancer cells</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Highlights • PCLP1 increases tumor cell resistance to NK cell-mediated lysis. • PCLP1 expressed on breast cancer cells decreases the levels of NK cell activating receptors. • PCLP1 localizes to the immunological synapse and is acquired by NK cells from tumor cells. • PCLP1 expressed on breast cancer cells impairs T cell proliferation.</description><subject>Antigens</subject><subject>Apoptosis</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - immunology</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>CD16 antigen</subject><subject>CD226 antigen</subject><subject>CD34 antigen</subject><subject>Cell Communication</subject><subject>Cell Proliferation</subject><subject>Cell surface</subject><subject>Coculture Techniques</subject><subject>Cytolysis</subject><subject>Cytotoxicity</subject><subject>Cytotoxicity, Immunologic</subject><subject>Dendritic cells</subject><subject>Dendritic Cells - immunology</subject><subject>Dendritic Cells - metabolism</subject><subject>Female</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Immune evasion</subject><subject>Immune response</subject><subject>Immunomodulation</subject><subject>Immunomodulators</subject><subject>Killer Cells, Natural - immunology</subject><subject>Killer Cells, Natural - metabolism</subject><subject>Kinases</subject><subject>Lymphocyte Activation</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>MCF-7 Cells</subject><subject>Metastases</subject><subject>Monoclonal antibodies</subject><subject>Natural killer cells</subject><subject>NK cells</subject><subject>NKG2 antigen</subject><subject>Plasma membranes</subject><subject>Podocalyxin</subject><subject>Receptors, Immunologic - immunology</subject><subject>Receptors, Immunologic - metabolism</subject><subject>Sialoglycoproteins - genetics</subject><subject>Sialoglycoproteins - immunology</subject><subject>Sialoglycoproteins - metabolism</subject><subject>Signal Transduction</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - metabolism</subject><subject>Time Factors</subject><subject>Transfection</subject><subject>Tumor cells</subject><subject>Tumor Escape</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqNkkuLFTEQhYMoznX0H4g0uHHTbd5JbwQZ1BEGFNSVi5BHXciddGdMusX7701zRwdmoxCozVcnp-oUQs8JHggm8vVh8HZOsAwUEzFgOWA6PkA7ohXt1ajxQ7TDDPOeaSbO0JNaDxhjwZV4jM6opEoqwnfo--ccsrfp-CvOfYrX0N2UvECcO9Lt19kvMc-1s-3NXZymdc5TDmuySy7HbsoJ_Jqga7grYOvSNU8eSuchpfoUPdrbVOHZbT1H396_-3px2V99-vDx4u1V7wXnSy_t6LSwQB1jWsgRnB154DoI6T0JeCSOKTc666wWXIaALRc-ELx3Voxqz87Rq5Nus_5jhbqYKdbNgZ0hr9UQRSlRklP9HyjWepRasIa-vIce8lrmNshGSaFGJkWj-InyJddaYG9uSpxsORqCzZaTOZhTTmbLyWBpWk6t7cWt-OomCH-b_gTTgDcnANrifkYopvoIbbchFvCLCTn-64f7Aj7FObaor-EI9W4WU6nB5st2K9upENGuhGjKfgP1v7qm</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Amo, Laura</creator><creator>Tamayo-Orbegozo, Estíbaliz</creator><creator>Maruri, Natalia</creator><creator>Buqué, Aitziber</creator><creator>Solaun, Miren</creator><creator>Riñón, Marta</creator><creator>Arrieta, Arantza</creator><creator>Larrucea, Susana</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7T5</scope></search><sort><creationdate>20151101</creationdate><title>Podocalyxin-like protein 1 functions as an immunomodulatory molecule in breast cancer cells</title><author>Amo, Laura ; Tamayo-Orbegozo, Estíbaliz ; Maruri, Natalia ; Buqué, Aitziber ; Solaun, Miren ; Riñón, Marta ; Arrieta, Arantza ; Larrucea, Susana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c544t-6a9b85ae2b338569eba94d48d56cc1d091b37b9baba8546dd0a45cd10fba597f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Antigens</topic><topic>Apoptosis</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - immunology</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>CD16 antigen</topic><topic>CD226 antigen</topic><topic>CD34 antigen</topic><topic>Cell Communication</topic><topic>Cell Proliferation</topic><topic>Cell surface</topic><topic>Coculture Techniques</topic><topic>Cytolysis</topic><topic>Cytotoxicity</topic><topic>Cytotoxicity, Immunologic</topic><topic>Dendritic cells</topic><topic>Dendritic Cells - immunology</topic><topic>Dendritic Cells - metabolism</topic><topic>Female</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Immune evasion</topic><topic>Immune response</topic><topic>Immunomodulation</topic><topic>Immunomodulators</topic><topic>Killer Cells, Natural - immunology</topic><topic>Killer Cells, Natural - metabolism</topic><topic>Kinases</topic><topic>Lymphocyte Activation</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>MCF-7 Cells</topic><topic>Metastases</topic><topic>Monoclonal antibodies</topic><topic>Natural killer cells</topic><topic>NK cells</topic><topic>NKG2 antigen</topic><topic>Plasma membranes</topic><topic>Podocalyxin</topic><topic>Receptors, Immunologic - immunology</topic><topic>Receptors, Immunologic - metabolism</topic><topic>Sialoglycoproteins - genetics</topic><topic>Sialoglycoproteins - immunology</topic><topic>Sialoglycoproteins - metabolism</topic><topic>Signal Transduction</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - metabolism</topic><topic>Time Factors</topic><topic>Transfection</topic><topic>Tumor cells</topic><topic>Tumor Escape</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amo, Laura</creatorcontrib><creatorcontrib>Tamayo-Orbegozo, Estíbaliz</creatorcontrib><creatorcontrib>Maruri, Natalia</creatorcontrib><creatorcontrib>Buqué, Aitziber</creatorcontrib><creatorcontrib>Solaun, Miren</creatorcontrib><creatorcontrib>Riñón, Marta</creatorcontrib><creatorcontrib>Arrieta, Arantza</creatorcontrib><creatorcontrib>Larrucea, Susana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amo, Laura</au><au>Tamayo-Orbegozo, Estíbaliz</au><au>Maruri, Natalia</au><au>Buqué, Aitziber</au><au>Solaun, Miren</au><au>Riñón, Marta</au><au>Arrieta, Arantza</au><au>Larrucea, Susana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Podocalyxin-like protein 1 functions as an immunomodulatory molecule in breast cancer cells</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>368</volume><issue>1</issue><spage>26</spage><epage>35</epage><pages>26-35</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Highlights • PCLP1 increases tumor cell resistance to NK cell-mediated lysis. • PCLP1 expressed on breast cancer cells decreases the levels of NK cell activating receptors. • PCLP1 localizes to the immunological synapse and is acquired by NK cells from tumor cells. • PCLP1 expressed on breast cancer cells impairs T cell proliferation.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>26276714</pmid><doi>10.1016/j.canlet.2015.06.029</doi><tpages>10</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0304-3835
ispartof Cancer letters, 2015-11, Vol.368 (1), p.26-35
issn 0304-3835
1872-7980
language eng
recordid cdi_proquest_miscellaneous_1722176428
source ScienceDirect Journals
subjects Antigens
Apoptosis
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - immunology
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
CD16 antigen
CD226 antigen
CD34 antigen
Cell Communication
Cell Proliferation
Cell surface
Coculture Techniques
Cytolysis
Cytotoxicity
Cytotoxicity, Immunologic
Dendritic cells
Dendritic Cells - immunology
Dendritic Cells - metabolism
Female
Hematology, Oncology and Palliative Medicine
Humans
Immune evasion
Immune response
Immunomodulation
Immunomodulators
Killer Cells, Natural - immunology
Killer Cells, Natural - metabolism
Kinases
Lymphocyte Activation
Lymphocytes
Lymphocytes T
MCF-7 Cells
Metastases
Monoclonal antibodies
Natural killer cells
NK cells
NKG2 antigen
Plasma membranes
Podocalyxin
Receptors, Immunologic - immunology
Receptors, Immunologic - metabolism
Sialoglycoproteins - genetics
Sialoglycoproteins - immunology
Sialoglycoproteins - metabolism
Signal Transduction
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
Time Factors
Transfection
Tumor cells
Tumor Escape
title Podocalyxin-like protein 1 functions as an immunomodulatory molecule in breast cancer cells
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T03%3A25%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Podocalyxin-like%20protein%201%20functions%20as%20an%20immunomodulatory%20molecule%20in%20breast%20cancer%20cells&rft.jtitle=Cancer%20letters&rft.au=Amo,%20Laura&rft.date=2015-11-01&rft.volume=368&rft.issue=1&rft.spage=26&rft.epage=35&rft.pages=26-35&rft.issn=0304-3835&rft.eissn=1872-7980&rft_id=info:doi/10.1016/j.canlet.2015.06.029&rft_dat=%3Cproquest_cross%3E1722176428%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c544t-6a9b85ae2b338569eba94d48d56cc1d091b37b9baba8546dd0a45cd10fba597f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1706579365&rft_id=info:pmid/26276714&rfr_iscdi=true