Diagnostic accuracy of super(18)F-FDG PET/CT compared with that of contrast-enhanced MRI of the breast at 3 T

• Published in: European journal of nuclear medicine and molecular imaging 2015-10, Vol.42 (11), p.1656-1665
• Main Authors: Magometschnigg, Heinrich F, Baltzer, Pascal A, Fueger, Barbara, Helbich, Thomas H, Karanikas, Georgios, Dubsky, Peter, Rudas, Margaretha, Weber, Michael, Pinker, Katja
• Format: Article
• Language: English
• ISSN: 1619-7070; 1619-7089
• DOI: 10.1007/s00259-015-3099-1

Purpose: To compare the diagnostic accuracy of prone super(18)F-FDG PET/CT with that of contrast-enhanced MRI (CE-MRI) at 3 T in suspicious breast lesions. To evaluate the influence of tumour size on diagnostic accuracy and the use of maximum standardized uptake value (SUV sub(MAX)) thresholds to differentiate malignant from benign breast lesions. Methods: A total of 172 consecutive patients with an imaging abnormality were included in this IRB-approved prospective study. All patients underwent super(18)F-FDG PET/CT and CE-MRI of the breast at 3 T in the prone position. Two reader teams independently evaluated the likelihood of malignancy as determined by super(18)F-FDG PET/CT and CE-MRI independently. super(18)F-FDG PET/CT data were qualitatively evaluated by visual interpretation. Quantitative assessment was performed by calculation of SUV sub(MAX). Sensitivity, specificity, diagnostic accuracy, area under the curve and interreader agreement were calculated for all lesions and for lesions