Selenium, nickel, and calcium levels in cancerous and non-cancerous prostate tissue samples and their relation with some parameters

In the present study, tissue samples of patients with cancerous and non-cancerous prostate were analyzed for their Se, Ni, and Ca contents. Possible relationship between Se, Ni, and Ca concentrations and some parameters including preoperative prostate-specific antigen (PSA) levels, histopathological...

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Bibliographic Details
Published in:Environmental science and pollution research international 2015-09, Vol.22 (17), p.13070-13076
Main Authors: Çelen, İlker, Müezzinoğlu, Talha, Ataman, O. Yavuz, Bakırdere, Sezgin, Korkmaz, Mehmet, Neşe, Nalan, Şenol, Feriye, Lekili, Murat
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Aged
Antigens
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
Calcium
Calcium - metabolism
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Environmental science
Enzymes
Humans
Limit of Detection
Male
Mass spectrometry
Middle Aged
Nickel
Nickel - metabolism
Patients
Prostate - metabolism
Prostate - surgery
Prostate cancer
Prostate-Specific Antigen - blood
Prostatectomy
Prostatic Hyperplasia - metabolism
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - surgery
Research Article
Risk Factors
Scientific imaging
Selenium
Selenium - metabolism
Seminal Vesicles
Studies
Tissues
Toxicity
Trace elements
Waste Water Technology
Water Management
Water Pollution Control
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Description
Summary:In the present study, tissue samples of patients with cancerous and non-cancerous prostate were analyzed for their Se, Ni, and Ca contents. Possible relationship between Se, Ni, and Ca concentrations and some parameters including preoperative prostate-specific antigen (PSA) levels, histopathological neurovascular invasion, extra-capsular extension, seminal vesicle invasion, positive surgical margins, PSA relapse after radical prostatectomy, and total Gleason scores were obtained. Inductively coupled plasma (ICP) optical emission spectrometry and ICP-mass spectrometry instruments were used for the determination of analytes interested. All the system parameters in digestion and measurement steps were optimized to obtain efficient digestion and sensitive measurements. There was no statistically meaningful difference observed in the concentration of selenium in cancerous and benign prostatic tissues ( p  = 0.347) while nickel levels in cancerous tissues were observed as significantly lower than benign tissues ( p  
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-015-4555-y