Plasmodium berghei ANKA infection results in exacerbated immune responses from C57BL/6 mice displaying hypothalamic obesity

MSG-obese mice infected with Plasmodium berghei ANKA produce high levels of pro inflammatory cytokines that could be activating leukocytes, leading to parasite elimination by itself or with other unknown mechanisms. However, this strong inflammatory process might be inducing brain damage and mice de...

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Bibliographic Details
Published in:Cytokine (Philadelphia, Pa.) Pa.), 2015-12, Vol.76 (2), p.545-548
Main Authors: de Carvalho, Renan Villanova Homem, Soares, Sara Malaguti Andrade, Gualberto, Ana Cristina Moura, Evangelista, Gabriela Coeli Menezes, Duque, Juliane Aparecida Marinho, Ferreira, Ana Paula, Macedo, Gilson Costa, Gameiro, Jacy
Format: Article
Language:English
Subjects:
Animals
Brain
Cytokines
Female
Hypothalamus - physiopathology
Malaria
Malaria - complications
Malaria - immunology
Male
Mice
Mice, Inbred C57BL
Obesity
Obesity - complications
Plasmodium berghei - isolation & purification
Systemic inflammation
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Summary:MSG-obese mice infected with Plasmodium berghei ANKA produce high levels of pro inflammatory cytokines that could be activating leukocytes, leading to parasite elimination by itself or with other unknown mechanisms. However, this strong inflammatory process might be inducing brain damage and mice death. Dashed black arrow represents unknown mechanisms. Dashed red arrows represent hypothetical effects. [Display omitted] •MSG-obese mice were able to better control the parasitemia compared to lean mice.•Obese mice succumb from Plasmodium berghei ANKA infection earlier than lean mice.•Obese mice display different patterns of cytokine production after ANKA infection.
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2015.01.025