Intensity modulated radiation therapy (IMRT) is not superior to three-dimensional conformal radiation (3DCRT) for adjuvant gastric radiation: A matched pair analysis

To compare three-dimensional conformal radiation (3DCRT) and Intensity Modulated Radiation Therapy (IG-IMRT) for adjuvant gastric irradiation. From Jan 2010-Aug 2013, all patients undergoing 3DCRT and IG-IMRT were included. Systemic chemotherapy included 1 cycle before and 2 cycles after chemoradiat...

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Bibliographic Details
Published in:Journal of cancer research and therapeutics 2015-07, Vol.11 (3), p.623-629
Main Authors: Chopra, Supriya, Agarwal, Aditi, Engineer, Reena, Dora, Tapas, Thomas, Biji, Sonawone, Supriya, Paul, Siji N, Kannan, Sadhna, Patil, Prachi, Mehta, Shaesta, Shrivastava, Shyam Kishore
Format: Article
Language:English
Subjects:
Adult
Aged
Cancer therapies
Chemotherapy
Compliance
Dissection
Female
Gastric cancer
Humans
Male
Matched-Pair Analysis
Medical imaging
Middle Aged
Planning
Radiation therapy
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Adjuvant - adverse effects
Radiotherapy, Conformal - adverse effects
Radiotherapy, Intensity-Modulated - adverse effects
Statistical analysis
Stomach Neoplasms - pathology
Stomach Neoplasms - radiotherapy
Tomography
Tumors
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Summary:To compare three-dimensional conformal radiation (3DCRT) and Intensity Modulated Radiation Therapy (IG-IMRT) for adjuvant gastric irradiation. From Jan 2010-Aug 2013, all patients undergoing 3DCRT and IG-IMRT were included. Systemic chemotherapy included 1 cycle before and 2 cycles after chemoradiation. Planning Target Volume (PTV) received 45 Gy/25 fractions/5 weeks with concurrent capcetabine 825 mg/m2 bid. Matched pair analysis was performed to evaluate imbalance in two cohorts if any. Common Toxicity Criteria for Adverse Event (CTCAE) vs 3.0 was used to record gastrointestinal (GI), hematological (HL), and renal toxicity during treatment and follow-up. Patterns of recurrence were documented. Mann-Whitney U test was used for statistical comparison. Of the 51 patients, 26 received 3DCRT and 25 IMRT. IMRT led to decrease in dose received by right and left kidney (12.4 Gy and 7.1 Gy and 29 Gy vs 8.2 Gy; P
ISSN:0973-1482
1998-4138
DOI:10.4103/0973-1482.150438