Exon Repetition in mRNA

The production of different transcripts (transcript heterogeneity) is a feature of many genes that may result in phenotypic variation. Several mechanisms, that occur at both the DNA and RNA level have been shown to contribute to this transcript heterogeneity in mammals, all of which involve either t...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1999-05, Vol.96 (10), p.5400-5405
Main Authors: Frantz, Simon A., Thiara, Amrik S., Lodwick, David, Ng, Leong L., Eperon, Ian C., Samani, Nilesh J.
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biological Sciences
Cells, Cultured
Complementary DNA
DNA
Exons
Exons - genetics
Genes
Genetics
Kidney Tubules, Proximal - metabolism
Kidneys
Liver
Liver - metabolism
Messenger RNA
Polymerase Chain Reaction
Proteins - genetics
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Repetitive Sequences, Nucleic Acid - genetics
Restriction Mapping
Reverse transcriptase polymerase chain reaction
Ribonuclease H - metabolism
Ribonucleic acid
RNA
RNA Processing, Post-Transcriptional - genetics
RNA, Messenger - genetics
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Summary:The production of different transcripts (transcript heterogeneity) is a feature of many genes that may result in phenotypic variation. Several mechanisms, that occur at both the DNA and RNA level have been shown to contribute to this transcript heterogeneity in mammals, all of which involve either the rearrangement of sequences within a genome or the use of alternative signals in linear, contiguous DNA or RNA. Here we describe tissue-specific repetition of selective exons in transcripts of a rat gene (SA) with a normal exon-intron organization. We conclude that nonlinear mRNA processing can generate tissue-specific transcripts.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.96.10.5400