Palladium-catalyzed one-pot synthesis of diazoles via tert-butyl isocyanide insertion

An efficient one-pot palladium-catalyzed reaction for the synthesis of diazoles from readily available hydrazides and aryl halide via isocyanide insertion/cyclization sequence has been developed. This methodology efficiently constructs diazoles in good to excellent yields with the advantages of wide...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2015-01, Vol.13 (41), p.10402-10408
Main Authors: Fan, Xiang-Yuan, Jiang, Xiao, Zhang, Ying, Chen, Zhen-Bang, Zhu, Yong-Ming
Format: Article
Language:English
Subjects:
Azoles - chemical synthesis
Azoles - chemistry
Catalysis
Cyclization
Molecular Structure
Nitriles - chemistry
Organometallic Compounds - chemistry
Palladium - chemistry
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Summary:An efficient one-pot palladium-catalyzed reaction for the synthesis of diazoles from readily available hydrazides and aryl halide via isocyanide insertion/cyclization sequence has been developed. This methodology efficiently constructs diazoles in good to excellent yields with the advantages of wide functional group tolerance and operational simplicity.
ISSN:1477-0520
1477-0539
DOI:10.1039/c5ob01328c