Synthesis of new kojic acid based unnatural α-amino acid derivatives

[Display omitted] An efficient method for the preparation of kojic acid based α-amino acid derivatives by alkylation of glycinate schiff base with bromokojic acids have been described. Using this method, mono as well as di alkylated kojic acid-amino acid conjugates have been prepared. This is the fi...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2015-11, Vol.25 (21), p.4753-4756
Main Authors: Balakrishna, C., Payili, Nagaraju, Yennam, Satyanarayana, Uma Devi, P., Behera, Manoranjan
Format: Article
Language:English
Subjects:
Alkylation
Amino Acids - chemical synthesis
Amino Acids - chemistry
Glycine
Hybrid molecule
Kojic acid
Molecular Structure
Pyrones - chemistry
Unnatural amino acid
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Summary:[Display omitted] An efficient method for the preparation of kojic acid based α-amino acid derivatives by alkylation of glycinate schiff base with bromokojic acids have been described. Using this method, mono as well as di alkylated kojic acid-amino acid conjugates have been prepared. This is the first synthesis of C-linked kojic acid-amino acid conjugate where kojic acid is directly linked to amino acid through a C–C bond.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2015.07.099