High sensitive C-reactive protein and the risk of acute kidney injury among ST elevation myocardial infarction patients undergoing primary percutaneous intervention

• Published in: Clinical and experimental nephrology 2015-10, Vol.19 (5), p.838-843
• Main Authors: Shacham, Yacov, Leshem-Rubinow, Eran, Steinvil, Arie, Keren, Gad, Roth, Arie, Arbel, Yaron
• Format: Article
• Language: English
• Subjects: Acute Kidney Injury - etiology; Acute Kidney Injury - mortality; Aged; Biomarkers - analysis; C-Reactive Protein - analysis; Electrocardiography; Female; Hospital Mortality; Humans; Intraoperative Complications - metabolism; Intraoperative Complications - mortality; Male; Medicine; Medicine & Public Health; Middle Aged; Myocardial Infarction - etiology; Myocardial Infarction - mortality; Nephrology; Original Article; Percutaneous Coronary Intervention - adverse effects; Percutaneous Coronary Intervention - mortality; Postoperative Complications - metabolism; Postoperative Complications - mortality; Predictive Value of Tests; Prognosis; Risk Factors; Treatment Outcome; Urology
• ISSN: 1342-1751; 1437-7799
• DOI: 10.1007/s10157-014-1071-1

Background Elevated periprocedural high sensitive C-reactive protein (hs-CRP) was shown to be associated with an increased risk for acute kidney injury (AKI) in non-myocardial infarction (MI) patients undergoing percutaneous coronary intervention (PCI), however, no information to date is present regarding its predicting role for AKI in MI patients. We evaluated whether admission serum hs-CRP levels may predict risk of AKI among ST elevation MI (STEMI) patients undergoing primary PCI. Methods Five hundred and sixty-two patients that were admitted with STEMI and treated with primary PCI were included in the study. Serum hs-CRP levels were determined from blood samples taken prior to PCI. Patients’ medical records were reviewed for occurrence of AKI, in-hospital complications and 30 days mortality. Results Mean age was 62 ± 16 and 455 (80 %) were males. Patients were divided into two groups, according to their admission hs-CRP values: group 1: hs-CRP ≤9 mg/l ( n  = 394) and group 2: hs-CRP >9 mg/l ( n  = 168). Patients with hs-CRP >9 mg/l had significantly higher rate of AKI following PCI (17 vs. 6 %; p  9 mg/l was an independent predictor for AKI (OR 2.7, 95 % CI: 1.39–5.29; p  = 0.001) and a strong trend for 30 day mortality (OR 4.27, 95 % CI: 0.875–21.10; p  = 0.07). Conclusion Admission serum hs-CRP level >9 mg/l is an independent predictor for AKI following primary PCI in STEMI patients.