Inkjet-Printed Gold Nanoparticle Surfaces for the Detection of Low Molecular Weight Biomolecules by Laser Desorption/Ionization Mass Spectrometry

Effective detection of low molecular weight compounds in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) is often hindered by matrix interferences in the low m/z region of the mass spectrum. Here, we show that monolayer-protected gold nanoparticles (AuNPs) can serve as alt...

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Bibliographic Details
Published in:Journal of the American Society for Mass Spectrometry 2015-11, Vol.26 (11), p.1931-1937
Main Authors: Marsico, Alyssa L. M., Creran, Brian, Duncan, Bradley, Elci, S. Gokhan, Jiang, Ying, Onasch, Timothy B., Wormhoudt, Joda, Rotello, Vincent M., Vachet, Richard W.
Format: Article
Language:English
Subjects:
Amino acids
Amino Acids - analysis
Analytical Chemistry
Bioinformatics
Biomolecules
Biotechnology
Chemistry
Chemistry and Materials Science
Desorption
Gold
Gold - chemistry
Inkjet printing
Ionization
Ions
Lasers
Low molecular weights
Mass spectrometry
Metal Nanoparticles - chemistry
Monolayers
Nanoparticles
Nanotechnology
Organic Chemistry
Printing
Proteomics
Research Article
Scientific imaging
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
Spectroscopy
Surface Properties
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Summary:Effective detection of low molecular weight compounds in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) is often hindered by matrix interferences in the low m/z region of the mass spectrum. Here, we show that monolayer-protected gold nanoparticles (AuNPs) can serve as alternate matrices for the very sensitive detection of low molecular weight compounds such as amino acids. Amino acids can be detected at low fmol levels with minimal interferences by properly choosing the AuNP deposition method, density, size, and monolayer surface chemistry. By inkjet-printing AuNPs at various densities, we find that AuNP clusters are essential for obtaining the greatest sensitivity. Graphical Abstract ᅟ
ISSN:1044-0305
1879-1123
DOI:10.1007/s13361-015-1223-x