Quercetin Enhances Chemosensitivity to Gemcitabine in Lung Cancer Cells by Inhibiting Heat Shock Protein 70 Expression

Micro-Abstract Quercetin is a bioflavonoid known for antioxidation and antiproliferation activities. We demonstrated that quercetin inhibited cancer cell growth and sensitized cancer cells to gemcitabine treatment by promoting apoptosis via inhibiting heat shock protein 70 expression. Our results su...

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Bibliographic Details
Published in:Clinical lung cancer 2015-11, Vol.16 (6), p.e235-e243
Main Authors: Lee, Seung Hyeun, Lee, Eun Joo, Min, Kyung Hoon, Hur, Gyu Young, Lee, Seung Heon, Lee, Sung Yong, Kim, Je Hyeong, Shin, Chol, Shim, Jae Jeong, In, Kwang Ho, Kang, Kyung Ho, Lee, Sang Yeub
Format: Article
Language:English
Subjects:
Adenocarcinoma - drug therapy
Adenocarcinoma - pathology
Adenocarcinoma of Lung
Apoptosis
Apoptosis - drug effects
Biomarkers, Pharmacological - metabolism
Caspases - metabolism
Cell Line, Tumor
Deoxycytidine - analogs & derivatives
Deoxycytidine - pharmacology
Gemcitabine
Gene Expression Regulation - drug effects
Heat shock protein
Hematology, Oncology and Palliative Medicine
HSP70 Heat-Shock Proteins - genetics
HSP70 Heat-Shock Proteins - metabolism
Humans
Lung cancer
Lung Neoplasms - drug therapy
Lung Neoplasms - pathology
Pulmonary/Respiratory
Quercetin
Quercetin - pharmacology
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Summary:Micro-Abstract Quercetin is a bioflavonoid known for antioxidation and antiproliferation activities. We demonstrated that quercetin inhibited cancer cell growth and sensitized cancer cells to gemcitabine treatment by promoting apoptosis via inhibiting heat shock protein 70 expression. Our results suggest that quercetin might have potential to increase sensitivity to chemotherapy and that heat shock protein 70 could be a new target for lung cancer treatment.
ISSN:1525-7304
1938-0690
DOI:10.1016/j.cllc.2015.05.006